Biomol Ther.  2014 Sep;22(5):467-473. 10.4062/biomolther.2014.063.

Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment

• Kim CY
• Lee GY
• Park GH
• Lee J
• Jang JH

• KMID: 2380326
• DOI: http://doi.org/10.4062/biomolther.2014.063

Abstract

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippo-campus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.

Keyword

Arabinoxylan; Brain-derived neurotrophic factor; cAMP response element binding protein; Learning and memory; Scopolamine

MeSH Terms

Administration, Oral
Amnesia
Animals
Brain-Derived Neurotrophic Factor
Cyclic AMP Response Element-Binding Protein
Dietary Fiber
Learning*
Maze Learning
Memory*
Rats
Rats, Sprague-Dawley
Scopolamine Hydrobromide
Triticum
Up-Regulation
Brain-Derived Neurotrophic Factor
Cyclic AMP Response Element-Binding Protein
Maze Learning
Scopolamine Hydrobromide