Biomol Ther.
2013 Jul;21(4):290-298.
Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis
- Affiliations
-
- 1Department of Preventive Medicine, School of Medicine, Catholic University of Daegu, Daegu 705-718, Repulic of Korea.
- 2The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Repulic of Korea. gucci200@hanmail.net
- 3Department of Preventive Medicine, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Repulic of Korea.
- 4Glucan Corporation and Marine Bio-Industry Development Center, Busan 617-806, Repulic of Korea.
- 5Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Repulic of Korea.
Abstract
- This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate- administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-alpha, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.
Keyword
MeSH Terms
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Animals
Arthritis
Arthritis, Rheumatoid*
Body Weight
Calcium Gluconate*
Calcium*
Cartilage
Collagen
Humans
Immunization
Immunomodulation
Interleukin-6
Knee
Knee Joint
Lymph Nodes
Male
Malondialdehyde
Mice*
Mice, Inbred DBA
Oxidative Stress
Peroxidase
Spleen
Tumor Necrosis Factor-alpha
Water*
Calcium
Calcium Gluconate
Collagen
Interleukin-6
Malondialdehyde
Peroxidase
Tumor Necrosis Factor-alpha
Water
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