Infect Chemother.
2014 Dec;46(4):226-238. 10.3947/ic.2014.46.4.226.
Clinical Importance and Epidemiology of Quinolone Resistance
- Affiliations
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- 1Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dhooper@mgh.harvard.edu
- 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- KMID: 2170491
- DOI: http://doi.org/10.3947/ic.2014.46.4.226
Abstract
- The quinolone class of antimicrobial agents is one of most widely used classes of antimicrobial agents in outpatient and inpatient treatment. However, quinolone resistance in gram-positive and gram-negative bacteria has emerged and increased globally. This resistance limits the usefulness of quinolones in clinical practice. The review summarizes mechanisms of quinolone resistance and its epidemiology and implications in the most common clinical settings, urinary tract infections, respiratory tract infections, intraabdominal infections, skin and skin structure infections, and sexually transmitted diseases.
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