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Evolution of Antimicrobial Resistance Levels of ESKAPE Microorganisms in a Peruvian IV-Level Hospital

Flores-Paredes W, Luque N, Albornoz R, Rojas N, Espinoza M, Pons MJ, Ruiz J

Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among...
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Colistin resistance and plasmidmediated mcr genes in Escherichia coli and Salmonella isolated from pigs, pig carcass and pork in Thailand, Lao PDR and Cambodia border provinces

Pungpian C, Lee S, Trongjit S, Sinwat N, Angkititrakul S, Prathan R, Srisanga S, Chuanchuen R

Background Colistin and carbapenem-resistant bacteria have emerged and become a serious public health concern, but their epidemiological data is still limited. Objectives This study examined colistin and carbapenem resistance in Escherichia coli and...
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Effect of 2% Chlorhexidine Bathing on the Incidence of Hospital-Acquired Infection and Multidrug-Resistant Organisms in Adult Intensive Care Unit Patients: Systematic Review and Meta-Analysis

Seo J, Song R

  • KMID: 2519546
  • J Korean Acad Nurs.
  • 2021 Aug;51(4):414-429.
Purpose: This systematic review and meta-analysis analyzed the effects of 2% chlorhexidine bathing on the incidence of hospital-acquired infection (HAI) and multidrug-resistant organisms (MDRO) in adult intensive care units. Methods:...
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The Impact of Antibiotic Burden on the Selective Resistance of Gram Negative Bacteria in Children

Park S, Lee E, So HJ, Yoo RN, Lee J

Background: The purpose of this study was to investigate the association between antibiotic use and the antimicrobial resistance of gram-negative bacteria isolated from blood cultures in a pediatric population. Methods: From...
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Identification and infection control of carbapenem-resistant Enterobacterales in intensive care units

Yi J, Kim KH

Infections with multidrug-resistant organisms among patients in intensive care units (ICUs) are associated with high mortality. Among multidrug-resistant organisms, carbapenem-resistant Enterobacterales (CRE) harbor important pathogens for healthcare-associated infections, including pneumonia,...
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Study of Conjunctival Microbial Flora in Patients of Intensive Care Unit

Ramani K, Kaliaperumal S, Sarkar S, Sistla S

Purpose: The objective of the study was to evaluate the type of conjunctival microbial flora in intensive care unit patients and their antimicrobial sensitivity pattern. Methods: A total of 272 samples...
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Machine Learning for Antibiotic Resistance Prediction: A Prototype Using Off-the-Shelf Techniques and Entry-Level Data to Guide Empiric Antimicrobial Therapy

Feretzakis G, Sakagianni A, Loupelis E, Kalles D, Skarmoutsou N, Martsoukou M, Christopoulos C, Lada M, Petropoulou S, Velentza A, Michelidou S, Chatzikyriakou R, Dimitrellos E

Objectives: In the era of increasing antimicrobial resistance, the need for early identification and prompt treatment of multi-drug-resistant infections is crucial for achieving favorable outcomes in critically ill patients. As...
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Types of 23S Ribosomal RNA Point Mutations and Therapeutic Outcomes for Helicobacter pylori

Kim SY, Park JM, Lim CH, Lee HA, Shin GY, Choe Y, Cho YK, Choi MG

Background/Aims: Point mutations in the 23S ribosomal RNA gene have been associated with Helicobacter pylori clarithromycin resistance. This study aimed to detect the prevalence of these point mutations and to...
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update

Chai JY, Jung BK, Hong SJ

The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule...
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Recent Trends in Tailored Treatments for Helicobacter pylori Infection

Park H, Lee JH

The efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin...
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Factors Influencing Self-Confidence in Performance of Infection Control for Multi-Drug Resistant Organisms among Nurses in Long-Term Care Hospitals

Lee SJ, Kim MR

Purpose: This was a descriptive research survey study to assess support for resources, organizational culture, knowledge, and self-confidence in the performance of infection control of multidrug-resistant organism (MDROs) perceived by...
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3D-culture models as drug-testing platforms in canine lymphoma and their cross talk with lymph nodederived stromal cells

An JH, Song WJ, Li Q, Bhang DH, Youn HY

Background: Malignant lymphoma is the most common hematopoietic malignancy in dogs, and relapse is frequently seen despite aggressive initial treatment. In order for the treatment of these recurrent lymphomas in...
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Antimicrobial Susceptibility Trends of Streptococcus pneumoniae by Age Groups Over Recent 10 Years in a Single Hospital in South Korea

Oh H, Heo ST, Kim M, Kim YR, Yoo JR

Purpose: Streptococcus pneumoniae (S. pneumoniae) causes respiratory tract infections. Its non-vaccine serotypes and multidrug-resistant pneumococcal diseases have increased during the post-pneumococcal vaccination era. Therefore, it is important to understand the...
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Continuing besifovir dipivoxil maleate versus switching from tenofovir disoproxil fumarate for treatment of chronic hepatitis B: Results of 192-week phase 3 trial

Song DS, Kim W, Ahn SH, Yim HJ, Jang JY, Kweon YO, Cho YK, Kim YJ, Hong GY, Kim DJ, Jung YK, Sohn JH, Lee JW, Park SJ, Lee BS, Kim JH, Kim HS, Yoon SK, Kim MY, Lee KS, Lim YS, Lee WS, Yang JM, Kim KH, Han KH, Um SH

Background/Aims: Besifovir dipivoxil maleate (BSV), an acyclic nucleotide phosphonate, shows potent antiviral activity against hepatitis B virus. Our previous 48-week trial revealed that BSV has comparable antiviral efficacy to tenofovir...
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Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing

Han J, Jung Y, Jun Y, Park S, Lee S

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in...
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Scalp Reconstruction Using Microvascular Free Tissue Transfer in the Patients with Intracranial Antibiotic-Resistant Bacteria Infection

Kim H, Lee S, Lee J, Shin S, Kim J, Suh I, Kim S

Purpose: When scalp infection occurs after craniectomy and cranioplasty, it tends to be recurrent and fatal. The infection can spread to the underlying tissue when the skull is not present...
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Salvage Regimens after Failure of Previous Helicobacter pylori Eradication Therapy: A Systematic Review and Meta-analysis

Yang HJ, Jung HK, Kang SJ, Lee YC, Park SY, Shin CM, Kim SE, Lim HC, Kim JH, Nam SY, Shin WG, Park JM, Choi IJ, Kim JG, Choi M, Korean College of Helicobacter and Upper Gastrointesinal Research

Background/Aims: As antibiotic resistance increases and new first-line therapies emerge, salvage therapies for Helicobacter pylori (H. pylori) eradication failures are becoming more common and complicated. This study aimed to systematically...
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The Current Strategy of Helicobacter pylori Eradication

Kwon YH

Helicobacter pylori (H. pylori) is the main cause of most gastroduodenal diseases. Triple therapy including two antibiotics, amoxicillin and clarithromycin, and a proton pump inhibitor given for a week has...
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Characterization of intracellular Ca2+ mobilization in gefitinib-resistant oral squamous carcinoma cells HSC-3 and -4

Kim MS, Kim MS

Oral squamous cell carcinoma (OSCC) metastasis is characterized by distant metastasis and local recurrence. Combined chemotherapy with cisplatin and 5-fluorouracil is routinely used to treat patients with OSCC, and the...
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Prevalence of plasmid-mediated AmpC β-lactamases among uropathogenic Escherichia coli isolates in southwestern Iran

Jomehzadeh N, Ahmadi K, Rahmani Z

Objectives: This study was undertaken to evaluate AmpC β-lactamase-producing Escherichia coli urine isolates and to characterize the frequency of plasmid-mediated AmpC (pAmpC)-encoding genes. Methods: Antimicrobial susceptibility tests were performed using the...
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