Infect Chemother.  2008 Aug;40(4):218-229. 10.3947/ic.2008.40.4.218.

Characterization of Respiratory Viral Infection in Children in Gwangju

• Seo JJ
• Kim MJ
• Kim SH
• Kee HY
• Chung JK
• Kim ES
• Park JT
• Kim KS
• Lee SY
• Kim MG
• Chung YS

• KMID: 2170237
• DOI: http://doi.org/10.3947/ic.2008.40.4.218

Abstract

BACKGROUND: This investigation was to perform the epidemiological surveillance and genetic analysis on respiratory viral agents from children with acute respiratory infections in Gwangju.
MATERIALS AND METHODS
For this study, 3,695 specimens obtained from patients with acute respiratory infections were collected by collaboration with pediatric hospitals in Gwangju between 2005 and 2007. Specimens were screened for 8 respiratory viruses including influenza viruses (IFV), human rhinoviruses (HRV), human coronaviruses (HCoV), adenoviruses (ADV), parainfluenza viruses (PIV), human enteroviruses (HEV), respiratory synthitial viruses (RSV) and human bocaviruses (HBoV). Respiratory viruses were detected using multiplex (RT) PCR with viral specific primers.
RESULTS
Out of 3,695 specimens, the ratio of virus detection was 24.9% (919). Overall, HRV (35.5%) and IFV (34.9%) were the most common viruses found, followed by HBoV (14.8%), HCoV (10.6%), RSV (3.7%), ADV (3.4%), PIV (3.2%) and HEV (3.0%). In addition, multiple infections were detected in 80 patients (8.7%). When the prevalence was analyzed according to season, HBoV, IFV and HCoV showed two epidemic points in late spring and early winter. ADV, HRV, RSV PIV and HEV, however, were all found to have only one epidemic point, with RSV being most common during winter and the others being most prominent during spring.
CONCLUSIONS
Through this epidemiological surveillance, the respiratory viruses prevalent in children in Gwangju area were investigated. We strongly recommend the development of nationwide policy for the management of prevalent respiratory virus that includes long term collection of data and samples, vaccine development and prevention education of the misuse of antibiotics.

Keyword

Respiratory Viral Infection; Multiplex RT-PCR; Children

MeSH Terms

Adenoviridae
Anti-Bacterial Agents
Child
Cooperative Behavior
Coronavirus
Enterovirus
Hospitals, Pediatric
Human bocavirus
Humans
Orthomyxoviridae
Paramyxoviridae Infections
Polymerase Chain Reaction
Prevalence
Respiratory Tract Infections
Rhinovirus
Seasons
Viruses
Anti-Bacterial Agents

Figure

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  Figure 1 Age and gender distribution in children with acute viral lower respiratory tract infections.

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  Figure 2 Monthly incidence patterns of respiratory tract infections detected from the children.

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