Pediatr Allergy Respir Dis.
1999 Jun;9(2):184-191.
IL-5 and IFN-gamma Levels in Nasopharyngeal Secretions from Non-Asthmatic Wheezing Children with Respiratory Syncytial Virus, Influenza A Virus Infection and Asthmatic Children
- Affiliations
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- 1Department of Pediatrics, Hanyang University, College of Medicine, Seoul, Korea.
- 2Department of Clinical Pathology, Hanyang University, College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Infection with respiratory virus has been shown to exacerbate asthma. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. And it also has been debated whether virus-induced wheezing in young children is an entity different from allergic asthma, or just a different expression of the same disease. In this study, we attempted to evaluate the importance of eosinophilic inflammation, comparing IL-5 and IFN-gamma levels in nasopharyngeal secretions in wheezing children with or without viral infection and the controls.
METHODS
We compared IL-5 and IFN-gamma levels in nasopharyngeal secretions from 38 non-asthmatic wheezing children with viral infections (RSV in 21 children, influenza A virus in 17 children), 12 asthmatic children without viral infections and 16 children as the controls.
RESULTS
The present study reported that RSV infection in children induced more releasing of IL-5 in nasopharyngeal secretions than the influenza A virus infected ones and the controls. On the other hand, the releasing of IFN-gamma levels in nasopharyngeal secretions from children with influenza A virus infection was significantly higher than those of the children with RSV infection or asthmatic children.
CONCLUSION
RSV infection in children may play a role in the immune response toward a Th2 phenotype as increasing IL-5 secretion in nasopharyngeal secretion. Increased IFN-gamma production in response to the influenza A virus infection may be related to the effective Th1 responses.
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