Allergy Asthma Respir Dis.  2015 May;3(3):180-186. 10.4168/aard.2015.3.3.180.

Comparison of short-term effects between subcutaneous and sublingual immunotherapies in children with house dust mite-sensitized allergic rhinitis and asthma

• Lee E
• Kim MJ
• Yang SI
• Yu J
• Hong SJ

• KMID: 2168487
• DOI: http://doi.org/10.4168/aard.2015.3.3.180

Abstract

PURPOSE
There have been several studies on comparisons of efficacy between subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in children with house dust mite (HDM)-sensitized allergic rhinitis (AR), without consistent results. This study was conducted to compare short-term effects between SCIT and SLIT in Korean children with HDM-sensitized AR.
METHODS
Fifty-three children (mean age, 11.15+/-2.82 years) with HDM-sensitized AR and with/without asthma (SCIT group, n=33; SLIT group, n=20) were enrolled. Clinical symptom scores and skin prick test results were assessed before, and after 3, 6, and 12 months of immunotherapy. Blood tests, including eosinophils, total serum IgE, and HDM-specific IgE, and adenosine 5'-monophosphate, and methacholine bronchial challenge tests were performed before and after 12 months of immunotherapy.
RESULTS
In the SCIT group, the symptom scores improved after 3 months compared to those before immunotherapy, whereas they improved after 6 months in the SLIT group. Significant decreases in skin reactivity to HDM were observed after 3 months only in the SCIT group. Decreases in total eosinophil counts and improvements in methacholine bronchial provocation tests were observed after 12 months of immunotherapy only in the SCIT group. No difference in severe adverse reactions was noted in either group.
CONCLUSION
The results of this study suggest that SCIT may have more rapid effects on clinical symptoms and skin reactivity in children with AR, compared to SLIT.

Keyword

Allergic rhinitis; Child; Dermatophagoides farinae; Dermatophagoides pteronyssinus; Immunotherapy

MeSH Terms

Adenosine
Asthma*
Bronchial Provocation Tests
Child*
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Dust*
Eosinophils
Hematologic Tests
Humans
Immunoglobulin E
Immunotherapy
Methacholine Chloride
Pyroglyphidae
Rhinitis*
Skin
Sublingual Immunotherapy*
Adenosine
Dust
Immunoglobulin E
Methacholine Chloride

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