Exp Neurobiol.  2015 Sep;24(3):206-210. 10.5607/en.2015.24.3.206.

Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties

Affiliations
  • 1Kirov Medical Academy, St. Petersburg 194 044, Russia.
  • 2Ioffe Physical-Technical Institute, St. Petersburg 194 026, Russia. a.elizarov@mail.ioffe.ru

Abstract

A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and cerebrospinal fluid for the study of blood-brain barrier (BBB) properties. Recent advanced a new membrane material was used for drug concentration measurement in biologic fluids. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane,hypnotic propofol, analgesic fentanyl. The selective detection of volatile anesthetic agents in blood does not require long-term sample processing before injecting the sample into mass-spectrometer interface, in contrast to chromatographic methods. Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia.

Keyword

membrane; mass-spectrometer; anesthesia; desflurane; fentanyl

MeSH Terms

Anesthesia
Anesthetics
Blood-Brain Barrier
Cerebrospinal Fluid*
Fentanyl*
Mass Spectrometry*
Membranes
Plasma*
Propofol*
Anesthetics
Fentanyl
Propofol
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