Korean J Anesthesiol.  1999 Apr;36(4):595-598. 10.4097/kjae.1999.36.4.595.

Inhibitory Effects of Cough Reflex Induced from Fentanyl According to the Dose of Propofol

• Chae YN
• Son Y

• KMID: 2091374
• DOI: http://doi.org/10.4097/kjae.1999.36.4.595

Abstract

BACKGROUND: Bronchodilation effect of propofol was known that it could prevent bronchoconstriction induced by fentanyl administration. The aim of this study was to investigate the dosage of propofol that inhibited cough reflex induced from fentanyl.
METHODS
One hundred twenty patients were randomly allocated to four groups: Group 1 (n=30, fentanyl 3 microgram/kg), Group 2 (n=30, propofol 0.5 mg/kg, fentanyl 3 microgram/kg), Group 3 (n=30, propofol 1 mg/kg, fentanyl 3 microgram/kg), Group 4 (n=30, propofol 2 mg/kg, fentanyl 3 microgram/kg). Patients in Group 1 were injected fentanyl within a second. Other patients groups were injected fentanyl two minutes after administration of propofol dosage, respectively. We checked cough response, oxygen desaturation and chest wall rigidity.
RESULTS
There was no significant difference in the incidence of cough response between Group 1 and 2. But, the incidence of Group 3 and 4 was significantly lower than in Group 1 and 2.
CONCLUSIONS
Propofol of clinical doses for anesthetic induction inhibit cough reflex induced from fentanyl.

Keyword

Anesthetics, intravenous, fentanyl, propofol; Complication, cough reflex

MeSH Terms

Bronchoconstriction
Cough*
Fentanyl*
Humans
Incidence
Oxygen
Propofol*
Reflex*
Thoracic Wall
Fentanyl
Oxygen
Propofol