Yeungnam Univ J Med.  1998 Jun;15(1):173-181. 10.12701/yujm.1998.15.1.173.

A case of Rifampin-induced Acute Renal Failure

Affiliations
  • 1Department of Internal Medicine, Pohang St. Mary's Hospital Pohang, Korea.
  • 2Department of Internal Medicine, College of Medicine, Yeungnam University Taegu, Korea.

Abstract

Rifampin is common drug to treat tuberculosis. Rifampin induced acute renal failure, hemolytic anemia and thrombocytopenia is rare and severe complication. We have experienced a case of rifampin induced acute renal failure, hemolytic anemia and thrombocytopenia. Forty-six years old male was suffered from reactivation of pulmonary tuberculosis, and had to medicate antituberculosis drugs including rifampin(600mg/day). Seven years ago, antituberdulosis medication were successfully administered to treat pulmonary tuberculosis without any side effects of drugs. But eight days after readministration of rifampin, fever, abdominal pain, vomiting, oliguria, elevated BUN and creatinine were developed. And thrombocytopenia was also identified after administration of rifampin. The patient was recovered slowly after discontinuation of rifampin & intensive medical care. The renal function was normalized at 55 days after cessation of rifampin. The renal pathologic findings were interstitial nephritis and acute tubular necrosis. And, the rifampin dependent antibodies were identified by indirect antiglobulin test in the presence of rifampin. So we report this case with a brief review of literature.

Keyword

Rifampin; Acute renal failure; interstitial nephritis

MeSH Terms

Abdominal Pain
Acute Kidney Injury*
Anemia, Hemolytic
Antibodies
Coombs Test
Creatinine
Fever
Humans
Male
Necrosis
Nephritis, Interstitial
Oliguria
Rifampin
Thrombocytopenia
Tuberculosis
Tuberculosis, Pulmonary
Vomiting
Antibodies
Creatinine
Rifampin
Full Text Links
  • YUJM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr