Korean J Blood Transfus.  2007 Apr;18(1):56-60.

A Case of Rifampin Induced Hemolytic Anemia Combined with Thrombocytopenia and Acute Renal Failure

• Ko C
• Kwon KC
• Park JW
• Koo SH
• Shin SY

Abstract

A 35 year old woman was admitted to the hospital owing to her nausea, vomiting, oliguria and petechia with re-administration of rifampin. Laboratory tests were performed and they showed a hemoglobin level of 8.6 g/dL, a leukocyte count of 7,660/microliter, a platelet count of 1,000/microliter, a blood urea nitrogen level of 92.3 mg/dL and a creatinine level of 10.6 mg/dL. The Direct Coombs' test and anti-platelet antibody test were positive. Hemolytic anemia combined with thrombocytopenia and acute renal failure related to rifampin was suspected. We proved the formation of immune complex with anti-rifampin antibody and rifampin by in vitro testing. Hemolytic anemia combined with thrombocytopenia and acute renal failure after treatment with rifampin is a rare condition. We report here on such a case along with a brief review of the related literature.

Keyword

Rifampin; Hemolytic anemia; Thrombocytopenia; Acute renal failure

MeSH Terms

Acute Kidney Injury*
Adult
Anemia, Hemolytic*
Antigen-Antibody Complex
Blood Urea Nitrogen
Coombs Test
Creatinine
Female
Humans
Leukocyte Count
Nausea
Oliguria
Platelet Count
Rifampin*
Thrombocytopenia*
Vomiting
Antigen-Antibody Complex
Creatinine
Rifampin