Korean J Nephrol.  2008 Nov;27(6):738-742.

A Case of Acute Interstitial Nephritis Complicated with Continuous Rifampin Therapy

• Kim HJ
• Cha JM
• Jung DE
• Lee JE
• Lee YM
• Shin JH
• Byun SJ
• Song JH
• Ahn SH

Abstract

Acute renal failure caused by rifampin typically occurs on intermittent administration or reintroduction of the drug. However, acute kidney injury (AKI) due to rifampin has been rarely reported to occur in patients receiving a continuous rifampin therapy. We have experienced a case of acute interstitial nephritis during the first course of standard anti-tuberculous therapy, including continuous rifampin therapy in daily dose. Forty-five-year-old male, who had been being treated with anti-tuberculous medication including rifampin (600 mg/day), was admitted to our hospital because of generalized edema and dyspnea by acute renal failure. His past medical history was unremarkable. Since the creatinine level was still elevated in 10 days after cessation of rifampin, we performed renal biopsy. The renal pathologic findings revealed acute interstitial nephritis. After that, the patient symptom was relieved and serum creatinine level was decreased without specific therapy. The renal function was recovered at 1 month after withdrawal of rifampin. We report a case of acute interstitial nephritis complicated with the first daily rifampin therapy, along with the review of literature.

Keyword

Rifampin; Interstitial nephritis; Acute renal failure

MeSH Terms

Acute Kidney Injury
Biopsy
Creatinine
Dyspnea
Edema
Humans
Male
Nephritis, Interstitial
Renal Insufficiency
Rifampin
Creatinine
Rifampin