Korean J Nephrol.  2000 Nov;19(6):1183-1186.

A Case of Carbamazepine-Induced Acute Interstitial Nephritis

• Chung JH
• Kim YK
• Kwon YE

Abstract

Acute interstitial nephritis is a disorder that primarily affect the renal tubule and interstitium. This disease may result from a variety of cause but drug have emerged as the most common cause of acute interstitial nephritis. Characteristically, in acute interstitial nephritis mononuclear cell infiltrate the interstitium, particularly in cortex. Diagnosis of acute intersitital nephritis can be made from historical information, physical examination,or laboratory test. But renal biopsy is the most definitive method of diagnosis. Carbamazepine has been used as a drug for treatment of convulsive disorder. This drug cause rarely renal problem. The authors experienced a case of carbamazepine induced acute interstitial nephritis in a 20 years old man who showed skin rash and mild fever, deminished renal function, and who was diagnosed by history,physical examination, renal biopsy.

Keyword

Acute interstitial nephritis; Acute renal failure; Carbamazepine

MeSH Terms

Acute Kidney Injury
Biopsy
Carbamazepine
Diagnosis
Exanthema
Fever
Humans
Nephritis
Nephritis, Interstitial*
Young Adult
Carbamazepine