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All about pain pharmacology: what pain physicians should know

Kim KH, Seo HJ, Abdi S, Huh B

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of...
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Trigeminal neuralgia management after microvascular decompression surgery: two case reports

Hwang V, Gomez-Marroquin E, Enciso R, Padilla M

Trigeminal neuralgia (TN) involves chronic neuropathic pain, characterized by attacks of repeating short episodes of unilateral shock-like pain, which are abrupt in onset and termination. Anticonvulsants, such as carbamazepine, are...
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Analysis of Adverse Drug Reactions with Carbamazepine and Oxcarbazepine at a Tertiary Care Hospital

Lee JE, Min KR, Kim SH, Kim AH, Kim ST

Purpose: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period. Materials and Methods: The frequency...
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Effect of carbamazepine on tetrodotoxin-resistant Na⁺ channels in trigeminal ganglion neurons innervating to the dura

Han JE, Cho JH, Nakamura M, Lee MG, Jang IS

Migraine is a neurological disorder characterized by recurrent and disabling severe headaches. Although several anticonvulsant drugs that block voltage-dependent Na⁺ channels are widely used for migraine, far less is known...
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Use of Video-oculography in the Diagnosis of Superior Oblique Myokymia

Chung SR, Lee TE, You IC, Cho NC, Ahn M

PURPOSE: Superior oblique myokymia is intermittent spontaneous contractions of the superior oblique muscle presenting as rapid and small-amplitude intorsions and depressions of the eye. The authors report a case of...
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Usefulness of Extracorporeal Treatment for Combined Intoxication with Controlled-Release Carbamazepine and Topiramate

Kim M, Kwon OY, Kim DH, Yoo S, Park DJ, Jeong H, Son S, Kim SK, Kang H, Park KJ, Choi NC, Lim B

Controlled-release carbamazepine (CBZ) could be more harmful than the regular form in special situations due to their respective biochemical characteristics. When primary treatment is not effective in acute intoxication, extracorporeal...
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Vestibular Paroxysmia Mimicking Benign Parxysmal Positional Vertigo

Cho HK, Lee YW, Park SH, Nam SI

Vestibular paroxysmia is the name given to the syndrome caused by vascular compression of the vestibulocochlear nerve. The main symptoms of vestibular paroxysmia are recurrent, spontaneous, brief attacks of spinning,...
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HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese

Nguyen DV, Chu HC, Nguyen DV, Phan MH, Craig T, Baumgart K, van Nunen

BACKGROUND: In Vietnam, we observed a high incidence of carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions (SCARs)-Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and drug-induced hypersensitivity rash with eosinophilia and systemic...
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Severe Resistant Hypertension Induced by Carbamazepine in an Elderly Patient

Kim SJ, Koh JA, Lee HC, Kim SE, Chu ST, Lee SH, Sir JJ, Choi SM, Joo SB, Lee HS, Han DH

We report a case of a 73-year-old patient with a 17 year-history of well-controlled primary hypertension with a single antihypertensive drug, which became uncontrolled since 9 months ago when he...
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Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice

Grewal AK, Jaggi AS, Rana AC, Singh N

The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant...
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Stevens-Johnson Syndrome Induced by Carbamazepine Treatment in a Patient Who Previously Had Carbamazepine Induced Pruritus: A Case Report

Bae HM, Park YJ, Kim YH, Moon DE

Stevens-Johnson syndrome (SJS) is a rare but life-threatening skin reaction disease and carbamazepine is one of its most common causes. We report a case of SJS secondary to carbamazepine in...
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A Case of Carbamazepine-induced DRESS Syndrome

  • KMID: 2090213
  • Korean J Asthma Allergy Clin Immunol.
  • 2011 Mar;31(1):59-62.
DRESS (Drug rash with eosinophilia and systemic symptoms) syndrome is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine and phenobarbital....
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Acute Hepatic Failure Associated with Stevens-Johnson Syndrome Induced by Carbamazepine Treatment in a Patient with Transverse Myelitis

Kim BS, Joo SH, Rhee HY, Park HC

Carbamazepine-induced liver injury is less common, but the consequences of the side effects can be very serious leading to death or a need for liver transplantation. We report a case...
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Successful Desensitization of Oxcarbazepine: First Case in Pediatric Patient

Lee OJ, Yu HJ, Lee CG, Nam SH, Lee BL, Lee J, Lee M

  • KMID: 2329490
  • J Korean Child Neurol Soc.
  • 2011 Dec;19(3):262-265.
Aromatic antiepileptic drugs (AEDs), such as diphenylhydantoin, phenobarbital, or carbamazepine (CBZ), are frequently associated with hypersensitivity reactions. This may restrict treatment options considerably due to cross reactivity with other aromatic...
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Severe Pain Attack Associated with Neurocardiogenic Syncope Induced by Glossopharyngeal Neuralgia: Successful Treatment with Carbamazepine and a Permanent Pacemaker: A Case Report

Kim SH, Han KR, Kim DW, Lee JW, Park KB, Lee JY, Kim C

Glossopharyneal neuralgia (GPN) is generally considered to be a pain disease. However, it can be also be a life-threatening cardiac cause of syncope. Neuralgia in the throat and neck can...
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Cataract Following Long-term Use of Carbamazepine in Young Adult

Park KI, Chung JM

  • KMID: 2065730
  • J Korean Neurol Assoc.
  • 2010 May;28(2):127-128.
No abstract available.
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A Case of Carbamazepine-Induced Peripheral Neuropathy

Lee SY, Koh ES, Kim K, Jung SH

  • KMID: 1470053
  • J Korean Epilepsy Soc.
  • 2009 Jun;13(1):27-30.
Peripheral neuropathy is rarely caused by antiepileptic drugs andmost cases were reported about phenytoin. Here we report carbamazepine- induced peripheral neuropathy, which is a very rare condition and the pathogenesis...
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Polymorphisms in the Voltage-gated Sodium Channel Genes and Antiepileptic Efficacy of Carbamazepine

Jang SY, Kim MK, Nam TS, Kim JT, Choi SM, Lee SH, Park MS, Kim BC, Cho KH

  • KMID: 2185031
  • J Korean Neurol Assoc.
  • 2009 May;27(2):147-153.
BACKGROUND: Voltage-gated sodium channels are responsible for the initial-depolarization component of action potentials in brain neurons, and hence they are the target for widely used antiepileptic drugs such as carbamazepine...
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Long-term Effectiveness and Tolerability of Topiramate in Children with Epilepsy under the Age of 2 Years: 4-Year Follow-up

Kim JM, Kwon S, Seo HE, Choe BH, Cho MH, Park SP

This is a long-term, open label, observational study aimed to broaden our clinical experiences in managing infants and toddlers with epilepsy. The long-term retention rate and side effects of topiramate...
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The Effects of Antiepileptic Drugs on Balance in Older People

Lee GH

  • KMID: 2185061
  • J Korean Neurol Assoc.
  • 2008 Aug;26(3):186-193.
BACKGROUND: The purpose of this study was to quantitatively assess the subclinical balance dysfunction in elderly people taking antiepileptic drugs. METHODS: We recruited sixty-three patients who were at least 50 years...
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