Immune Netw.  2011 Dec;11(6):324-335. 10.4110/in.2011.11.6.324.

HLA and Disease Associations in Koreans

• Ahn S
• Choi HB
• Kim TG

• KMID: 2150716
• DOI: http://doi.org/10.4110/in.2011.11.6.324

Abstract

The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and disease associations have been widely studied across the populations world-wide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. Because recently developed molecular based HLA typing has several advantages like improved specimen stability and increased resolution of HLA types, the association between HLA alleles and a given disease could be more accurately quantified. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, drug responsiveness and other diseases with unknown etiology in Koreans and attempt to summarize some remarkable HLA alleles related with specific diseases.

Keyword

HLA; Disease association; Korean

MeSH Terms

Alleles
Autoimmune Diseases
Chromosomes, Human, Pair 6
Clinical Coding
Communicable Diseases
Disease Susceptibility
Genetic Variation
Histocompatibility Testing
Humans
Immune System
Leukocytes
Major Histocompatibility Complex
Proteins
Transplants
Proteins

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