Yonsei Med J.  1983 Jun;24(1):33-37. 10.3349/ymj.1983.24.1.33.

HLA-DR Antigens and HLA-B: DR Haplotypes in Koreans

• Kim SJ
• Choi IH
• Kim JD

• KMID: 1758484
• DOI: http://doi.org/10.3349/ymj.1983.24.1.33

Abstract

HLA-DR antigen and gene frequencies were studied in 150 unrelated Koreans in Seoul. HLA-DR4 was the most common DR specificity encountered and HLA-DR1 and -DR3 occurred with the lowest frequencies. The frequency of HLA-DR blank allele was 27.1%. HLA-B:DR haplotypes involving positive delta values differing significantly from zero were DR1:B7, DR2:Bw22, DR3:B17, DR5:Bw35, DRw6:B17, DR7:B12, DR7:B13, and DRw8:Bw16. The supertypic groups (MT1, MT2 and MT3) differ somewhat in frequencies from Other populations. These findings suggested that the Korean population, while having many similarities in HLA-DR antigen frequencies with those of neighboring Orientals, has not only different features in the distribution of HLA-DR antigens but also has unique HLA-B:DR haplotypes.

Keyword

HLA-DR antigens; HLA-B:DR haplotypes; Korean

MeSH Terms

Gene Frequency
HLA Antigens/analysis*
HLA-B Antigens
HLA-DR Antigens
Haploidy
Histocompatibility Antigens Class II/analysis*
Human
Korea
Mongoloid Race*