Korean J Anesthesiol.  2015 Oct;68(5):434-441. 10.4097/kjae.2015.68.5.434.

Neonatal anesthesia: how we manage our most vulnerable patients

• Bang SR

• KMID: 2148650
• DOI: http://doi.org/10.4097/kjae.2015.68.5.434

Abstract

Neonates undergoing surgery are at higher risk than older children for anesthesia-related adverse events. During the perioperative period, the maintenance of optimal hemodynamics in these patients is challenging and requires a thorough understanding of neonatal physiology and pharmacology. Data from animals and human cohort studies have shown relation of the currently used anesthetics may associate with neurotoxic brain injury that lead to later neurodevelopmental impairment in the developing brain. In this review, the unique neonatal physiologic and pharmacologic features and anesthesia-related neurotoxicity will be discussed.

Keyword

Anesthetics; Neurotoxicity syndromes; Newborn infant; Parental consent

MeSH Terms

Anesthesia*
Anesthetics
Animals
Brain
Brain Injuries
Child
Cohort Studies
Hemodynamics
Humans
Infant, Newborn
Neurotoxicity Syndromes
Parental Consent
Perioperative Period
Pharmacology
Physiology
Anesthetics