- Monitored Anesthesia Care for Cardiovascular Interventions
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Song JW, Soh S, Shim JK
- KMID: 2465658
- Korean Circ J.
- 2020 Jan;50(1):1-11.
- doi: 10.4070/kcj.2019.0269
The interventional cardiology is growing and evolving. Many complex procedures are now performed outside the operating room to manage cardiovascular pathologies which had been traditionally treated with cardiac surgery. Appropriate... -
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- The problem of medicating women like the men: conceptual discussion of menstrual cycle-dependent psychopharmacology
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Yum SK, Yum SY, Kim T
- KMID: 2467966
- Transl Clin Pharmacol.
- 2019 Dec;27(4):127-133.
- doi: 10.12793/tcp.2019.27.4.127
While hormonal changes during the ovulatory cycles affect multiple body systems, medical management, including medication dosing remains largely uniform between the sexes. Little is known about sex-specific pharmacology in women.... -
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- Treatment response and disease progression
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Holford N
- KMID: 2467965
- Transl Clin Pharmacol.
- 2019 Dec;27(4):123-126.
- doi: 10.12793/tcp.2019.27.4.123
This tutorial defines the concepts of disease progression in the context of clinical pharmacology. Disease progression describes the natural history of disease, such as pain, or biomarker of drug response,... -
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- Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea
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Kim KK
- KMID: 2462242
- J Korean Med Assoc.
- 2019 Nov;62(11):588-597.
- doi: 10.5124/jkma.2019.62.11.588
Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and... -
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- Ethnobotany, Phytochemistry, and Pharmacology of Angelica decursiva Fr. et Sav.
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Ali MY, Seong SH, Jannat S, Jung HA, Choi JS
- KMID: 2459959
- Nat Prod Sci.
- 2019 Sep;25(3):181-199.
- doi: 10.20307/nps.2019.25.3.181
Angelica decursiva Fr. et Sav. (Umbelliferae) has traditionally been used to treat different diseases due to its antitussive, analgesic, and antipyretic activities. It is also a remedy for thick phlegm,... -
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- Adverse drug reactions
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Cho MK, Kang DY, Kang HR
- KMID: 2459156
- J Korean Med Assoc.
- 2019 Sep;62(9):472-479.
- doi: 10.5124/jkma.2019.62.9.472
There are no drugs without the risk of potential adverse reactions. All pharmacologically active substances can cause adverse drug reactions (ADRs). This paper aims at introducing recent trends in pharmacosurveillance... -
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- Non-compartmental data analysis using SimBiology and MATLAB
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Park JS, Kim JR
- KMID: 2458947
- Transl Clin Pharmacol.
- 2019 Sep;27(3):89-91.
- doi: 10.12793/tcp.2019.27.3.89
MATLAB® is widely used for numerical analysis, modeling, and simulation. One of MATLAB's tools, SimBiology®, is often used for pharmacokinetic, pharmacodynamic model and dynamic systems; however, SimBiology seems to be... -
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- Evolving role of modeling and simulation in drug development
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Lim HS
- KMID: 2442242
- Transl Clin Pharmacol.
- 2019 Mar;27(1):19-23.
- doi: 10.12793/tcp.2019.27.1.19
Pharmacokinetic-pharmacodynamic model is a kind of language that quantitatively describes the drug-related outcomes in the form of mathematical formula. Various outcomes can be subjected to modeling analysis if they can... -
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- Digital therapeutics and clinical pharmacology
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Chung JY
- KMID: 2442240
- Transl Clin Pharmacol.
- 2019 Mar;27(1):6-11.
- doi: 10.12793/tcp.2019.27.1.6
Digital therapeutics (DTx) is a new subsection of digital health that is primarily driven by software and will be of great interest to clinical pharmacologists. In this article, an overview... -
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- Translational and Clinical Pharmacology: Note from the new Editor-in-Chief
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Shin SG
- KMID: 2442238
- Transl Clin Pharmacol.
- 2019 Mar;27(1):1-1.
- doi: 10.12793/tcp.2019.27.1.1
No abstract available. -
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- STADIUM: Species-Specific tRNA Adaptive Index Compendium
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Yoon J, Chung YJ, Lee M
- KMID: 2439218
- Genomics Inform.
- 2018 Dec;16(4):e28.
- doi: 10.5808/GI.2018.16.4.e28
Due to the increasing interest in synonymous codons, several codon bias-related terms were introduced. As one measure of them, the tRNA adaptation index (tAI) was invented about a decade ago.... -
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- Pharmacodynamic principles and target concentration intervention
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Holford N
- KMID: 2429509
- Transl Clin Pharmacol.
- 2018 Dec;26(4):150-154.
- doi: 10.12793/tcp.2018.26.4.150
This tutorial reviews the principles of dose individualisation with an emphasis on target concentration intervention (TCI). Once a target effect is chosen then pharmacodynamics can predict the target concentration and... -
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- Derivation of pharmacokinetic equations
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Noh GJ
- KMID: 2435992
- Anesth Pain Med.
- 2018 Oct;13(4):349-362.
- doi: 10.17085/apm.2018.13.4.349
A variety of drugs are continuously or intermittently administered to patients during general or regional anesthesia. Pharmacotherapy should also receive priority compared with several treatment modalities including nerve blocks for... -
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- Survey on the undergraduate curriculum in clinical pharmacology and interns' prescribing ability in South Korea
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Gu N, Kim KJ, Lim CY, Lee JK, Rhee MY, Shin KH, Lee SH, Ahn S
- KMID: 2420295
- Transl Clin Pharmacol.
- 2018 Sep;26(3):128-133.
- doi: 10.12793/tcp.2018.26.3.128
Appropriate prescription writing is one of the critical medical processes affecting the quality of public health care. However, this is a complex task for newly qualified intern doctors because of... -
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- Mechanistic ligand-receptor interaction model: operational model of agonism
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Kim H, Lim HS
- KMID: 2420293
- Transl Clin Pharmacol.
- 2018 Sep;26(3):115-117.
- doi: 10.12793/tcp.2018.26.3.115
This tutorial explains the basic principles of mechanistic ligand-receptor interaction model, which is an operational model of agonism. A growing number of agonist drugs, especially immune oncology drugs, is currently... -
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- Regional clinical pharmacology trials for Multi-Regional clinical trials
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Jang IJ
- KMID: 2420290
- Transl Clin Pharmacol.
- 2018 Sep;26(3):101-102.
- doi: 10.12793/tcp.2018.26.3.101
No abstract available. -
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- Improvement in Ovarian Tissue Quality with Supplementation of Antifreeze Protein during Warming of Vitrified Mouse Ovarian Tissue
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Kong HS, Kim EJ, Youm HW, Kim SK, Lee JR, Suh CS, Kim SH
- KMID: 2418799
- Yonsei Med J.
- 2018 Mar;59(2):331-336.
- doi: 10.3349/ymj.2018.59.2.331
Ice easily recrystallizes during warming after vitrification, and antifreeze protein (AFP) can inhibit the re-crystallization. However, no study has evaluated the effect of AFP treatment only thereon during warming. This... -
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- The Role of Serotonin in Ventricular Repolarization in Pregnant Mice
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Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B
- KMID: 2418792
- Yonsei Med J.
- 2018 Mar;59(2):279-286.
- doi: 10.3349/ymj.2018.59.2.279
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
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Kim B, Choi KM, Yim HS, Park HT, Yim JH, Lee MG
- KMID: 2418853
- Yonsei Med J.
- 2018 Jan;59(1):85-91.
- doi: 10.3349/ymj.2018.59.1.85
PURPOSE: Ascorbic acid has been reported to have an adipogenic effect on 3T3-L1 preadipocytes, while evidence also suggests that ascorbic acid reduces body weight in humans. In this study, we... -
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