Transl Clin Pharmacol.  2016 Dec;24(4):157-160. 10.12793/tcp.2016.24.4.157.

Absorption and Half-Life

• Holford N

• KMID: 2413836
• DOI: http://doi.org/10.12793/tcp.2016.24.4.157

Abstract

This tutorial deals with basic concepts of absorption processes and links previous tutorials on clearance and volume of distribution to introduce the concept of half-life. The time course of both absorption and elimination are commonly described using a half-life. Half-life can also be used to describe drug accumulation. Understanding the principles underlying the time course of absorption and elimination are essential in pharmacotherapy and clinical pharmacology.

Keyword

absorption; half-life; pharmacokinetics; clinical pharmacology

MeSH Terms

Absorption*
Drug Therapy
Half-Life*
Pharmacokinetics
Pharmacology, Clinical

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