- Absorption and Half-Life
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Holford N
- KMID: 2413836
- Transl Clin Pharmacol.
- 2016 Dec;24(4):157-160.
- doi: 10.12793/tcp.2016.24.4.157
This tutorial deals with basic concepts of absorption processes and links previous tutorials on clearance and volume of distribution to introduce the concept of half-life. The time course of both... -
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- The Prognostic Significance of the Half-life Serum CA 125 During Therapy in Epithelial Ovarian Carcinoma
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Park JS, Kim KT, Chung SR, Hwang YY, Moon H, Kim DS
- KMID: 2083709
- Korean J Gynecol Oncol Colposc.
- 1992 Mar;3(1):48-60.
Twenty-eight patients with epithelial ovarian carcinoma were serially monitored with the CA 125 antigenic determinant to assess the prognost,ic significance of the half-life of serum CA 125 during therapy. The... -
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- Clinical Significance of the Actual Half-life of Serum Alpha-fetoprotein in Primary Hepatocellular Carcinoma
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Chung CW, Choi JS, Kim BR
- KMID: 2209404
- J Korean Surg Soc.
- 2001 Jun;60(6):644-648.
PURPOSE: We observed the actual half life of the alpha-fetoprotein (AFP) had clinical meaning in that it reflected the long term prognosis more individually at a certain level of preoperative... -
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- Lesion-Wise Comparison of Pre-Therapy and Post-Therapy Effective Half-Life of Iodine-131 in Pediatric and Young Adult Patients with Differentiated Thyroid Cancer Undergoing Radioiodine Therapy
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Kumar P, Bal C, Damle NA, Ballal S, Dwivedi SN, Agarwala S
- KMID: 2450010
- Nucl Med Mol Imaging.
- 2019 Jun;53(3):199-207.
- doi: 10.1007/s13139-019-00592-z
PURPOSE: The effective half-life of radioiodine is an important parameter for dosimetry in differentiated thyroid cancer patients, particularly in children. We determined the pre-therapy and post-therapy effective half-life in different... -
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- Comparison of clinical efficacy between acitretin and etretinate in psoriasis
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Moon SE, Kim BS, Youn JI, Lee YS
- KMID: 2230930
- Korean J Dermatol.
- 1992 Jun;30(3):354-361.
Etretinate, an effective retinoid in the treatment of pustular, erythrodermic and chronic plaque type psoriasis, has the disadvantage of a long terminal elimination half-life. On the other hand, acitretin, the... -
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- Elimination half-lives of interleukin-6 and cytokine-induced neutrophil chemoattractant-1 synthesized in response to inflammatory stimulation in rats
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Kuribayashi T
- KMID: 2413847
- Lab Anim Res.
- 2018 Jun;34(2):80-83.
- doi: 10.5625/lar.2018.34.2.80
The elimination half-lives of in Interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) in rats after inflammatory stimulation were investigated. Five male Sprague-Dawley rats were used (age, 9 weeks; body weight,... -
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- How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles
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Park JC
- KMID: 2148006
- Anesth Pain Med.
- 2015 Oct;10(4):235-244.
- doi: 10.17085/apm.2015.10.4.235
Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation.... -
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- Progress of Hemophilia A Therapeutics in Korea
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Kim DH, Kim SK
- KMID: 2435419
- Clin Pediatr Hematol Oncol.
- 2018 Apr;25(1):17-22.
- doi: 10.15264/cpho.2018.25.1.17
Over the past several decades, hemophilia treatment in Korea has progressed dramatically. It has become possible to prevent hemophilia complications by maintenance treatment as well as on-demand treatment with the... -
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- Oral Riboflavine Tetrabutyrate Therapy for Psoriasis
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Key CJ, Koh CJ, Cho BK
- KMID: 2085502
- Korean J Dermatol.
- 1979 Apr;17(2):117-121.
Riboflavine tetrabutyrate is a fat soluble riboflavine derivative. It was synthesized by esterification of riboflavine with fatty acid chloride or by esterification of riboflavine with fatty acid anbydride. The advantage... -
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- Pharmacodynamic principles and the time course of immediate drug effects
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Holford N
- KMID: 2406995
- Transl Clin Pharmacol.
- 2017 Dec;25(4):157-161.
- doi: 10.12793/tcp.2017.25.4.157
This tutorial defines the principles of the concentration - effect relationship which are the basis of pharmacodynamics. The two key parameters of pharmacodynamics are the maximum response (Emax) and the... -
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- Midazolam Pharmacokinetics in Patients Undergoing Lung Surgery
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Lee SI, Kim SS, Hwang GB, Lee JH
- KMID: 2154473
- Korean J Anesthesiol.
- 1997 Nov;33(5):822-828.
- doi: 10.4097/kjae.1997.33.5.822
BACKGROUND: The nature of operation alters the volume of distribution at steady state (Vdss) of drug. The hepatic extraction ratio of midazolam (0.3~0.7) could be influenced by hepatic blood flow... -
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- Actual Half-Life of Alpha-Fetoprotein as a Prognostic Tool in Pediatric Malignant Tumors
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Han SJ, Oh JT, Yoo SY, Choi SH, Hwang EH
- KMID: 2095220
- J Korean Surg Soc.
- 1997 Apr;52(4):566-571.
In a retrospective study, the prognostic value of monitoring the decay of alpha-fetoprotein (AFP) was assessed. Serum AFP was determined serially in 18 children with malignant germ cell tumors or... -
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- Significance of postoperative serum level of carcinoembryonic antigen (CEA) and actual half life of CEA in colorectal cancer patients
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Choi JS, Min JS
- KMID: 699923
- Yonsei Med J.
- 1997 Feb;38(1):1-7.
- doi: 10.3349/ymj.1997.38.1.1
The postoperative levels of carcinoembryonic antigen (CEA) and the actual half life (T1/2) of CEA were evaluated to ascertain their potency in predicting the recurrence of colorectal cancer... -
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- Antibiotic therepy in renal failure
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Cho BS
- KMID: 2440549
- Korean J Pediatr Infect Dis.
- 1996 May;3(1):66-74.
- doi: 10.14776/kjpid.1996.3.1.66
There continues to be increasing the number of patients being treated for renal failure day by day due to lot of causes. It is prerequsite for the physician to have... -
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- Effective Half-life of I-131 in Patients with Differentiated Thyroid Cancer Treated by Radioactive I-131
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Park SG
- KMID: 2036493
- Nucl Med Mol Imaging.
- 2008 Dec;42(6):464-468.
PURPOSE: Effective half life of I-131 (T(eff)) in patients with differentiated thyroid cancer treated by I-131 is must-know value for dose calculation and determination of release time from isolation room.... -
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- A Case Report of Triazolam Dependence: Focusing Anxiety Symptoms and Treatment
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Park JH, Cho YG
- KMID: 2340298
- J Korean Neuropsychiatr Assoc.
- 1999 Mar;38(2):424-435.
Benzodiazepines, which used to and would be prescribed frequently as anxiolytic sedative hypnotics not only in psychiatric field but also in almost all clinical departments, are prone to develop tolerance,... -
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- Clearance
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Holford N, Yim DS
- KMID: 2351806
- Transl Clin Pharmacol.
- 2015 Dec;23(2):42-45.
- doi: 10.12793/tcp.2015.23.2.42
This tutorial deals with basic concepts of clearance, the most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration and elimination rate... -
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- Pattern of Decrease of Prostate Specific Antigen after Radical Radiotherapy for the Prostate Cancer
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Kim BK, Park SW, Ha SW
- KMID: 2323717
- J Korean Soc Ther Radiol Oncol.
- 1999 Jun;17(2):136-140.
PURPOSE: Prostate specific antigen (PSA) is a useful tumor marker, which is widely used as a diagnostic index and predictor of both treatment and follow-up result in prostate cancer. A... -
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- Volume of Distribution
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Holford N, Yim DS
- KMID: 2290472
- Transl Clin Pharmacol.
- 2016 Jun;24(2):74-77.
- doi: 10.12793/tcp.2016.24.2.74
This tutorial deals with basic concepts of volume of distribution, the second most important parameter in pharmacokinetics but often challenging for students in clinical pharmacology. Its relationships with dose, concentration... -
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- Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis
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Zhang L, Zhao L, Liu Y, Liu J, Li X
- KMID: 2398501
- J Vet Sci.
- 2017 Dec;18(4):431-437.
- doi: 10.4142/jvs.2017.18.4.431
A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of... -
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