Cancer Res Treat.  2002 Jun;34(3):205-211.

Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk

• Kim SU
• Lee KM
• Park SK
• Yoo KY
• Noh DY
• Choe KJ
• Ahn SH
• Kang D

Abstract

PURPOSE: To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.
RESULTS
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).
CONCLUSION
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.

Keyword

Breast neoplasm; Genetic polymorphism; Glutathione S-transferase

MeSH Terms

Alcohol Drinking
Alleles
Breast Neoplasms*
Breast*
Case-Control Studies
Female
Genotype
Glutathione Transferase*
Glutathione*
Humans
Korea
Logistic Models
Polymerase Chain Reaction
Polymorphism, Genetic*
Risk Factors
Glutathione
Glutathione Transferase