Korean Circ J.  1997 Mar;27(3):279-286. 10.4070/kcj.1997.27.3.279.

Influences of the Apolipoprotein E Polymorphism on the Development of Coronary Artery Disease and on Serum Lipids in the Korean Males

• Ryu JC
• Kim DK
• Kim JW
• Park WH
• Choi JS
• Choo JA
• Choi YR
• Kim MK
• Cho BR
• Gwon HC
• Park SW
• Kim JS
• Lee SH
• Hong KP
• Kim DW
• Park JE
• Lee WR

• KMID: 2093599
• DOI: http://doi.org/10.4070/kcj.1997.27.3.279

Abstract

BACKGROUND
Apo E lipoprotein is polymorphic and exists in three common isoforms (E2, E3 and E4), which are the gene products of three apo E alleles, e2, e3 and e4. Apo E lipoprotein plays an important role in the regulation of the lipid metabolism through its ability to bind to receptors. Depending on the genotypes apo E polymorphism is either protective or increases risk for atherosclerosis and coronary artery disease. The purpose of this study is to evaluate 1) the association between apo E allele and the development of coronary artery disease, 2) the association between apo E alleles and dyslipidemia in Korean males.
METHODS
We studied 241 patients with angiographically verified coronary artery disease and 257 male subjects without evidence of coronary artery disease. Apo E genotyping was determined with the INNO-LiPA Apo E kit (Innogenetics, Belgium), which is based on reverse hybridization.
RESULTS
There was a higher frequency of the apo e4 allele in subjects with coronary artery disease than in normal controls. The frequencies of apo E genotype were not significantly associated with apo e2 were associated with higher levels of triglyceride and lower LDL, and the subjects with apo e4 had lower levels of HDL cholesterol.
CONCLUSION
ApoE polymorphism is a genetic marker for risk of the development of coronary artery disease and an important determinant of dyslipidemia.

Keyword

Apo E polymorphism; Coronary artery disease; Lipid

MeSH Terms

Alleles
Apolipoprotein E2
Apolipoprotein E4
Apolipoproteins E
Apolipoproteins*
Atherosclerosis
Cholesterol, HDL
Coronary Artery Disease*
Coronary Vessels*
Dyslipidemias
Genetic Markers
Genotype
Humans
Lipid Metabolism
Lipoproteins
Male*
Protein Isoforms
Triglycerides
Apolipoprotein E2
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E
Cholesterol, HDL
Genetic Markers
Lipoproteins
Protein Isoforms