Korean J Med.
2001 Sep;61(3):240-248.
Cyclooxygenase-2 and vascular endothelial growth factor (VEGF) expression in colorectal polyps
- Affiliations
-
- 1Department of Internal Medicine, Dongguk University College of Medicine, Gyungju, Korea.
- 2Department of Pathology, Dongguk University College of Medicine, Gyungju, Korea.
- 3Department of Preventive Medicine, Dongguk University College of Medicine, Gyungju, Korea.
- 4Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
- 5Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea.
- 6Department of Pathology, Korea University College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND
Recent studies showed that non-steroidal antiinflammatory drug may reduce the risk of colorectal cancers. So its potential target, cyclooxygenase (COX)-2 in colorectal cancers has been widely investigated. However, the rate and patterns of COX-2 expression in colorectal polyps have been quite variable among study groups. Furthermore, its role has not been established. The study aim is to investigate the expressions of COX-2 and vascular endothelial growth factor (VEGF) and to evaluate the role of COX-2 in colorectal polyps.
METHODS
Fifty-seven colorectal polyps from endoscopic polypectomy or surgical resection were enrolled. Polyps were as follows; 9 were hyperplastic polyps, 14 mild, 26 moderate dysplasia, 8 high grade adenomas (5 severe dysplasia, a carcinoma in situ, and two intramucosal carcinomas). They were stained for COX-2 and VEGF by immunohistochemistry. The intensity of staining according to histologic grades and size of polyp was semi-quantitatively assessed.
RESULTS
COX-2 was expressed in 18 cases (31.8%) by dysplastic epithelium and 29 cases (50.9%) by interstitial cells. Epithelial COX-2 expressions were significantly related to histologic grades and size, and begun at moderate dysplasia actually. Interstitial COX-2 was little related to histologic grades and size. VEGF was expressed in 35 cases (61.4%). There was close relationship between epithelial COX-2 and VEGF expressions.
CONCLUSION
COX-2 is expressed both in dysplastic epithelium and interstitial cells of colorectal polyps. Our results suggest that epithelial COX-2 expression may be playing a role in tumorigenesis of colorectal polyp, possibly involved in angiogenesis with VEGF.
MeSH Terms
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Adenoma
Carcinogenesis
Carcinoma in Situ
Colorectal Neoplasms
Cyclooxygenase 2*
Endothelial Growth Factors
Epithelium
Immunohistochemistry
Polyps*
Prostaglandin-Endoperoxide Synthases
Vascular Endothelial Growth Factor A*
Cyclooxygenase 2
Endothelial Growth Factors
Prostaglandin-Endoperoxide Synthases
Vascular Endothelial Growth Factor A
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