J Korean Soc Coloproctol.  2008 Dec;24(6):433-438. 10.3393/jksc.2008.24.6.433.

Expression of Vascular Endothelial Growth Factor in Colorectal Cancer

• Jo TW
• Lim SC
• Kim S
• Min YD
• Kim KJ

• KMID: 2198858
• DOI: http://doi.org/10.3393/jksc.2008.24.6.433

Abstract

PURPOSE: The neovascularization is an essential factor for the growth of solid organ cancer and especially vascular endothelial growth factor (VEGF) has been known to the very important mediator of neovascularization. Thus, this study was searching that expression of VEGF in colorectal cancer correlate to clinicopathologic factors.
METHODS
We analyzed 93 patients with sporadic colorectal cancer who underwent colectomy and their specimens were studied immunohistochemistry at Chosun University hospital from March, 2002 to November, 2005.
RESULTS
The expression rate of VEGF was 61 cases of all (65.6%). There were no significant relation VEGF expression to age, sex and lymph node metastasis. But, VEGF expression in colon cancer was 80.5% rather than 53.8% in rectal cancer (P=0.010). Correlation with T staging, expression of VEGF was 10.0% in pT0, 62.5% in pT1, pT2 and 77.2% in pT3, pT4 (P<0.0001), and correlation with TNM staging, expression of VEGF was 10.0% in stage 0, 63.2% in stage I, 72.0% in stage II, 73.3% in stage III and 100.0% in stage IV (P=0.001).
CONCLUSIONS
Expression of VEGF in colorectal cancer closely correlates with cancer progression and VEGF was more expressed in colon cancer than rectum.

Keyword

VEGF; Colorectal cancer; Cancer progression

MeSH Terms

Colectomy
Colonic Neoplasms
Colorectal Neoplasms
Humans
Immunohistochemistry
Lymph Nodes
Neoplasm Metastasis
Neoplasm Staging
Rectal Neoplasms
Rectum
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor A