Korean J Obstet Gynecol.
2002 Sep;45(9):1588-1594.
Effects of supplementation of folic acid, multiminerals, DHA on fertility rate of rats and growth and learning ability of their offsprings
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA university School of Medicine, Korea.
- 2Korea Food Research Institute, Korea.
- 3Natural Medical Institute, Goeulbit SengSik MaEul Co., Korea.
- 4Department of Food and Nutrition, Sungshin Women's university, Korea.
- 5Department of Food and Nutrition, Hallym university, Korea.
Abstract
OBJECTIVE
Malnutrition and nutritional disorder may cause problem of fertility and therefore adequate nutrition is very important during pregnancy. In this study, we investigated effects of supplemental diet contained folic acid, zinc, calcium, Iron, DHA and taurine on fertility outcome in the female rats and learning ability of their offsprings.
METHODS
The female rats at 4 week were fed by two group divided control (AIN-76 diet) and supplement diet. The male rats were taken pellet type diet. After 3 weeks, female rats and male rats were mated. Then, at 3 weeks after mating, parturition was begun. After paturition, sex and birth weight of offsprings were examined for their offsprings. When the offsprings were 3 weeks of age, position reversional test in a water maze was done for 4 weeks. After female rats were fed experimental diet for 4 weeks, their follicle, corpus luteum, corpus albicans, progesterone, estradiol and ovary weight were measured.
RESULTS
22 rats of 30 in supplemental diet group succeeded on parturition, and 11 rats of 30 in control group succeeded. Pregnancy outcome was fine in both group. There was no significant difference in weight of major bowels and femur length of their offspring. The position reversional test of offsprings in a water maze showed a significant difference between control group and supplement group. Elapsed time and errorneous response to reach the escape platform were significantly lowered in supplemental group than control group.
CONCLUSION
This result suggest that supplementation contained folic acid, multivitamins, DHA and taurine may increase fertility rate in the maternal rats and also learning ability in offsprings.
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