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Intelectin-1 and Endocrinological Parameters in Women with Polycystic Ovary Syndrome: Effect of Insulin Resistance

Al-Fartosy AJM, Awad NA, Mohammed A

OBJECTIVES: We aimed to evaluate the effect of insulin resistance (IR) on serum Intelectin-1 and endocrinological hormones levels in obese and non-obese women with and without polycystic ovary syndrome (PCOS)...
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The Effect of Trigonella foenum-graceum L. (Fenugreek) Towards Collagen Type I Alpha 1 (COL1A1) and Collagen Type III Alpha 1 (COL3A1) on Postmenopausal Woman's Fibroblast

Yusharyahya SN, Bramono K, Sutanto NR, Kusuma I

Trigonella foenum-graceum L. (fenugreek) is a phytoestrogen, a nonsteroidal organic chemical compound from plants which has similar mechanism of action to sex hormone estradiol-17β. This study aims to assess the...
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Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice

Lee J, Lee HC, Kim SY, Cho GJ, Woodruff T

PURPOSE: The aim of this study was to investigate how type I diabetes mellitus (T1D) affects the folliculogenesis and oocyte development, fertilization, and embryo development. MATERIALS AND METHODS: A comparative animal...
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Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development

Son HJ, Sohn SH, Kim N, Lee HN, Lee SM, Nam RH, Park JH, Song CH, Shin E, Na HY, Kim JS, Lee DH, Surh YJ

PURPOSE: This study demonstrates that estradiol downregulates inflammation and inhibits colorectal cancer (CRC) development in azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model. MATERIALS AND METHODS: AOM/DSS-treated male and female mice were sacrificed...
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The Effects of Menopausal Hormone Therapy on Serum Level of C-reactive Protein in Postmenopausal Korean Women

Shin W, Kim SE, Lee JY, Seo JW, Hyun HS, Suh JH, Choi D, Yoon BK

OBJECTIVES: Inflammation is a major mechanism underlying coronary heart disease (CHD) and C-reactive protein (CRP) is a marker of inflammation. When administered soon after menopause, menopausal hormone therapy (MHT) prevents...
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Effect of Vitamin D on the Vaginal Health of Menopausal Women: A Systematic Review

Riazi H, Ghazanfarpour M, Taebi M, Abdolahian S

Menopause is associated with the onset of climacteric symptoms due to low estradiol levels, which may cause insufficient maturation of the vaginal mucosa. Vitamin D may regulate the growth and...
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Estrogen-secreting adrenocortical carcinoma

Jeong Y, Cho SC, Cho HJ, Song JS, Kong JS, Park JW, Ku YH

Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete...
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Prevalence of CYP17A1 gene mutations in 17α-hydroxylase deficiency in the Chinese Han population

Wang M, Wang H, Zhao H, Li L, Liu M, Liu F, Meng F, Fan C

BACKGROUND: 17α-hydroxylase deficiency is a rare autosomal recessive disorder caused by mutations in the cytochrome P450 family 17 subfamily A member 1 gene. The major clinical presentation includes hypertension, hypokalemia,...
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Ginkgo biloba extract (EGb761) did not express estrogenic activity in an immature rat uterotrophic assay

Moon B, Kim W, Park CH, Oh SM

Ginkgo biloba is a dioecious tree that has been used in traditional Chinese medicine for about 5,000 years. In previous studies on Ginkgo biloba extract (EGb761) using in vitro systems,...
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High Estradiol Differentially Affects the Expression of the Glucose Transporter Type 4 in Pelvic Floor Muscles of Rats

de los Ángeles Carrasco-Ruiz , Hernández-Aragón LG, Chávez-Ríos JR, Rodríguez-Antolín J, Pacheco P, Martínez-Gómez M, Cuevas-Romero E, Castelán

PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were...
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The influence of hormone therapy with drospirenone-estradiol on endometrioid type endometrial cancer patients

Lim S, Kim YH, Lee KB, Lee JM

OBJECTIVE: To determine whether drospirenone/estradiol (DRSP/E2) has an adverse effect on clinical outcomes in surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I/II endometrial cancer (EC) patients. METHODS: In...
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Dental Panoramic Radiographic Indices as a Predictor of Osteoporosis in Postmenopausal Saudi Women

Balto KA, Gomaa MM, Feteih RM, AlAmoudi N, Elsamanoudy AZ, Hassanien , Ardawi MS

BACKGROUND: Many oral presentations of osteoporosis-a bone metabolic disease-were recorded. Thus, we aimed to assess panoramic radiomorphometric indices with bone mineral density (BMD) values among Saudi postmenopausal women and its...
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Porcine intestinal lymphoid tissues synthesize estradiol

Park CJ, Kim H, Jin J, Barakat R, Lin PC, Choi JM, Ko CJ

Estradiol (17β-estradiol) is synthesized primarily in the gonads of both sexes and regulates the development and function of reproductive organs. Recently, we reported that intestinal lymphocyte homeostasis is regulated by...
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Delayed puberty versus hypogonadism: a challenge for the pediatrician

Bozzola M, Bozzola E, Montalbano C, Stamati FA, Ferrara P, Villani A

Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty (DP), is mainly found in males, and is characterized by short stature and delayed skeletal...
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The serum estradiol/oocyte ratio in patients with breast cancer undergoing ovarian stimulation with letrozole and gonadotropins

Shim YJ, Seol A, Lee D, Kim SK, Lee JR, Jee BC, Suh CS, Kim SH

OBJECTIVE: To investigate the patterns of estradiol-oocyte ratio (EOR) and estradiol-mature oocyte ratio (EMOR) in patients with breast cancer undergoing controlled ovarian stimulation (COS) using letrozole and gonadotropins for fertility...
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Age of Postmenopause Women: Effect of Soy Isoflavone in Lipoprotein and Inflammation Markers

Barrasa GR, González Cañete N, Boasi LE

OBJECTIVES: Menopause is associated with adverse metabolic changes in plasma lipoprotein and inflammation markers. Estrogens have beneficial effects on lipid metabolism and inflammation. Isoflavones (ISO) have structurally similar to estradiol....
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The effect of Puerariae Radix on ovariectomy-induced bone loss in C3H/HeN mice

Ahn B, Lee S, Kang S, Moon C, Kim JC, Jang JS, Kim SH

Osteoporosis is a major worldwide public health problem that poses a great economic burden to society. Puerariae Radix, the dried root of Pueraria lobata (Wild.) Ohwi, has been widely used...
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Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice (Mus musculus)

Ahmad B, Shrivastava VK, Saleh R, Henkel R, Agarwal A

OBJECTIVE: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role...
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Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells

Zandieh Z, Amjadi F, Vakilian H, Aflatoonian K, Amirchaghmaghi E, Fazeli A, Aflatoonian R

OBJECTIVE: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3...
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Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model

Song CH, Kim N, Sohn SH, Lee SM, Nam RH, Na HY, Lee DH, Surh YJ

BACKGROUND/AIMS: Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBDs) such as ulcerative colitis. This dysfunction is caused by increased permeability and the loss of tight junctions in...
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