Korean J Obstet Gynecol.  2001 Mar;44(3):587-593.

The relationship among (CA) repeat polymorphism of interleukin(IL)-6 gene, serum IL-6 levels and bone mineral density

• Kim JG
• Kim SH
• Choi YM
• Moon SY
• Lee JY

Abstract

OBJECTIVE
To investigate the relationship between cytosine-adenosine(CA) polymorphism in interleukin-6 (IL-6) gene, serum IL-6 levels and bone mineral density (BMD).
METHODS
IL-6 CA polymorphism was analyzed by polyacrylamide-urea gel electrophoretic patterns in 300 postmenopausal Korean women. and direct DNA sequencing. Serum IL-6 was measured by enzyme linked immunosorbent assay, and BMD at the lumbar spine and proximal femur by dual energy X-ray absorptiometry.
RESULTS
Nine alleles were observed with product sizes ranging between 120-136 bp and 125 allele was the most common. There were no significant differences in serum IL-6 levels and BMD at the lumbar spine and proximal femur between the women who possessed at least one allele of each genotype and those who did not posses that allele. Serum IL-6 levels did not correlated with age, menopause duration, body mass index and BMD at the lumbar spine and proximal femur. IL-6 CA polymorphic pattern and serum IL-6 levels in osteoporotic women were not different from those in normal BMD or osteopenic women.
CONCLUSIONS
IL-6 CA polymorphism has no relationship with serum IL-6 levels and BMD in postmenopausal Korean women.

Keyword

Postmenopausal women; IL-6; gene polymorphism; BMD

MeSH Terms

Absorptiometry, Photon
Alleles
Body Mass Index
Bone Density*
Enzyme-Linked Immunosorbent Assay
Female
Femur
Genotype
Humans
Interleukin-6*
Menopause
Sequence Analysis, DNA
Spine
Interleukin-6