J Reprod Endocrinol.  2012 Oct;4(2):132-139.

The Relationship between Interleukin-10 -592A>C Polymorphism, Bone Mineral Density and Bone Response after Hormone Therapy in Postmenopausal Korean Women

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. kimjg@plaza.snu.ac.kr
  • 2Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

Abstract


OBJECTIVES
To investigate the association between interleukin (IL)-10 -592A>C gene polymorphisms, pre-hormone therapy (HT) and post-HT bone mineral density (BMD) and biochemical bone markers and in postmenopausal Korean women.
METHODS
The IL-10 -592A>C polymorphism was analyzed by Taqman assay in 373 postmenopausal Korean women. Serum biochemical markers including CrossLaps (CTX) and bone alkaline phosphatase (BAP) and serum osteoprotegerin (OPG)-soluble receptor activator of nuclear factor-kB (sRANKL) were measured by enzyme linked immunosorbent assay. The BMD was determined at the lumbar spine (LS) and femoral neck (FN) by dual energy X-ray absorptiometry. BMDs and bone markers were also measured after HT.
RESULTS
No significant differences were found in adjusted BMD at LS and FN or in risk for osteoporosis according to the genotypes of the IL-10 -592A>C polymorphism. Statistical significances were neither observed in serum levels of bone chemical markers and serum OPG-sRANKL. There were no significant differences in change of BMD or bone markers after HT according to the genotypes of the IL-10 -592A>C polymorphism.
CONCLUSION
The IL-10 -592A>C polymorphism did not demonstrate a significant effect on BMD at the lumbar spine and femoral neck in postmenopausal Korean women.

Keyword

Bone biochemical markers; Bone mineral density; Genetic polymorphism; Hormone therapy; IL-10

MeSH Terms

Absorptiometry, Photon
Alkaline Phosphatase
Biomarkers
Bone Density
Collagen
Enzyme-Linked Immunosorbent Assay
Female
Femur Neck
Genotype
Humans
Interleukin-10
Interleukins
Osteoporosis
Osteoprotegerin
Peptide Fragments
Polymorphism, Genetic
Spine
Alkaline Phosphatase
Collagen
Interleukin-10
Interleukins
Osteoprotegerin
Peptide Fragments
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