Korean J Psychopharmacol.
2000 Mar;11(1):67-72.
Effect of Repeated Stress on the Antioxidant Activities of Brain
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Yeungnam University, Taegu, Korea.
- 2Department of Pharmacology, College of Medicine, Yeungnam University, Taegu, Korea.
- 3Department of Psychiatry, Kyungju Hospital, College of Medicine, Dongguk University, Kyungju, Korea.
Abstract
OBJECTIVES
Behavioral stress has been suggested as one of important factors which destruct the physiologic antioxidant system. Studies about antioxidant activity changes in brain by repeated stress may be valuable data in the clarification of pathogenesis and development of treatment modalities for the psychologic stress-induced somatic disease.
METHODS
We examined, therefore, immobilization stress -induced antioxidant defense chages in the rat brain. Superoxide dismutase, glutathione peroxidase and, glutathione reductase activities were measured in the dissected specimens of the cerebral cortex, hippocampus, striatum, brain stem, cerebellum and hypothalamus of adult male Sprague-Dawley rats subjected to 2 hour immobilization stress for 14 consecutive days.
RESULTS
In this study, immobilization inhibited glutathione peroxidase and glutathione reductase activities in striatum and hypothalamus than any other brain regions.
CONCLUSION
These results suggest that striatum and hypothalmus are subject to strong pro-oxidant impacts arising at the repeated immobilization stress.
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