J Korean Neurosurg Soc.  2010 Sep;48(3):301-304. 10.3340/jkns.2010.48.3.301.

Metronidazole Induced Encephalopathy in a Patient with Brain Abscess

• Bahn Y
• Kim E
• Park C
• Park HC

• KMID: 2066826
• DOI: http://doi.org/10.3340/jkns.2010.48.3.301

Abstract

Metronidazole is commonly used for brain abscess but is not well known for its neurotoxic complications. Metronidazole-induced encephalopathy (MIEP) is toxic encephalopathy associated with the use of metronidazole. We experienced a case of brain abscess which developed reversible severe MIEP during treatment period. Although MIEP occurs in typical locations, it is not easy to differentiate from other conditions such as cerebral infarction, demyelinating diseases and metabolic diseases. Neurosurgeons should be aware that severe MIEP can occur during the use of metronidazole though it is not common.

Keyword

Metronidazole; Brain abscess; Toxic encephalopathy

MeSH Terms

Brain
Brain Abscess
Cerebral Infarction
Demyelinating Diseases
Humans
Metabolic Diseases
Metronidazole
Neurotoxicity Syndromes
Metronidazole