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The Current Strategy of Helicobacter pylori Eradication

Kwon YH

Helicobacter pylori (H. pylori) is the main cause of most gastroduodenal diseases. Triple therapy including two antibiotics, amoxicillin and clarithromycin, and a proton pump inhibitor given for a week has...
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The Efficacy of Skin Care Habit Modifications on the Skin Barrier Function in Rosacea Patients

Seol JE, Cho GJ, Ahn SW, Hong SM, Park SH, Jung SY, Kim H

  • KMID: 2524132
  • Korean J Dermatol.
  • 2021 Dec;59(10):770-777.
Background: Patients with rosacea usually suffer from skin irritations, such as itching, stinging, burning, and pain. These symptoms may be related to the skin barrier function disruption. Objective: We investigated the skin...
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Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection

Lee GH, Lee KM, Shin SJ, Kang JK, Noh CK, Kim JH, Lim SG

Background/Aims: The negative effects on the eradication success of Helicobacter pylori infection after previous exposure to macrolides, including clarithromycin on clarithromycin-based first-line therapy have been demonstrated. However,whether this is...
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Metronidazole in the Management of Post-Open Haemorrhoidectomy Pain: Systematic Review

Re AD, Toh JWT, Iredell J, Ctercteko

Purpose: Open haemorrhoidectomy is associated with significant postoperative pain. Metronidazole is commonly prescribed in the postoperative period as an adjunct to analgesia in pain management. Methods: In our systematic review, studies...
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Encapsulation of Low Metronidazole Dose in Poly (D,L-lactide-co-glycolide) (PLGA) Nanoparticles Improves Giardia intestinalis Treatment

Madbouly NA, Nashee H, Elgendy AA, Rabee I, Amir AE

Background: The present study was designed to investigate the antigiardial efficacy of low metronidazole dose loaded-D.L-lactide-co-glycolide (LMD-PLGA) nanoparticles (NPs) and to compare it with the standard high dose of metronidazole...
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Clindamycin-doxycycline-metronidazole combination therapy in a refractory canine babesiosis case

An HM, Song JH, An SJ, Yu DH, Han D, Kim YJ, Jung DI

An 8-year-old castrated male Maltese dog (patient) was referred to our institute with refractory canine babesiosis. The patient had previously responded to conventional treatment with atovaquone and azithromycin; however, anemia...
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Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam

Van Khien , Thang DM, Hai TM, Duat NQ, Khanh PH, Ha DT, Binh TT, Dung HD, Trang TT, Yamaoka Y

Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole,...
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Clinical Usefulness of Prophylactic Metronidazole after Head and Neck Cancer Surgery

Choi IH, Lee H, Kim YC, Jung KY, Baek SK

BACKGROUND AND OBJECTIVES: Head and neck cancer surgery has a high risk of infection, because surgical fields are exposed to the oral cavity and the pharynx during surgery. The purpose...
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A Case of Metronidazole-Induced Encephalopathy: Atypical Involvement of the Brain on MRI

Hwang E, Chang SK, Lee SA, Choi JA

Metronidazole is an antimicrobial agent widely used for the treatment of anaerobic infection or antibiotics-associated diarrhea. It is generally thought to be safe, but can induce reversible toxic encephalopathy in...
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Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study

Amin SA, Gawdat SI

OBJECTIVES: This study compared the retention of BioAggregate (BA; Innovative BioCeramix) and mineral trioxide aggregate (MTA; Angelus) as coronal plugs after applying different intracanal medications (ICMs) used in regenerative endodontics. MATERIALS...
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Preserved Efficacy of Oral Metronidazole for Severe Clostridium difficile Infection

Yu SN, Lee EJ

OBJECTIVE: Although clinical practice guidelines recommend oral vancomycin for hospitalized patients with severe Clostridium difficile infection (CDI), oral metronidazole is still the preferred regimen due to its tolerability and low...
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Comparison of the efficacy of amoxicillin-clavulanic acid with metronidazole to azithromycin with metronidazole after surgical removal of impacted lower third molar to prevent infection

Sayd S, Vyloppilli S, Kumar K, Subash P, Kumar N, Raseel S

OBJECTIVES: The goal of the study was to investigate the clinical effects of amoxicillin-clavulanic acid (500+125 mg) with metronidazole 400 mg administered three times daily (Group I) versus azithromycin 500...
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Metronidazole-Induced Encephalopathy with Thiamine Deficiency

Kim RY, Lee DS, Gwag BC, Lee YK, Cheon SM, Jeong JH

Metronidazole-induced encephalopathy (MIE) can be caused by excessive dose or prolonged metronidazole administration. The signal abnormalities in the cerebellar dentate nuclei, midbrain, dorsal pons and corpus callosum on magnetic resonance...
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Atorvastatin: In-Vivo Synergy with Metronidazole as Anti-Blastocystis Therapy

Basyoni MM, Fouad SA, Amer MF, Amer AF, Ismail DI

Blastocystis is an enteric Straminopile in tropical, subtropical and developing countries. Metronidazole has been a chemotheraputic for blastocystosis. Failures in its regimens were reported and necessitate new studies searching for...
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Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant Therapy for Helicobacter pylori Infection

Jung JH, Cho IK, Lee CH, Song GG, Lim JH

BACKGROUND/AIMS: The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant...
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Optimal First-line Eradication Regimens for Helicobacter pylori Infection in Patients with Clarithromycin Resistance: A Pilot Study

Seo MW, Jeong YJ, Kim JS, Kim BW

BACKGROUND/AIMS: Helicobacter pylori eradication rates using first-line treatment have decreased due to clarithromycin resistance. The aim of this study was to investigate optimal eradication regimens for patients with clarithromycin resistance...
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Oculogyric Crisis Due to Metronidazole Toxic Encephalopathy

Lee SW, Kim H, Heo D, Park JH

Oculogyric crisis is an acute dystonia involving ocular muscles characterized by sustained conjugate upward or lateral deviation of the eyes. Metronidazole is a commonly used antimicrobial agent in treatment of...
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Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease

Shinzaki S, Fujii T, Bamba S, Ogawa M, Kobayashi , Oshita M, Tanaka H, Ozeki K, Takahashi , Kitamoto H, Kani K, Nanjo S, Sugaya T, Sakakibara Y, Inokuchi T, Kakimoto K, Yamada A, Yasuhara H, Yokoyama Y, Yoshino T, Matsui A, Nakamura M, Tomizawa T, Sakemi R, Kamata N, Hibi T

BACKGROUND/AIMS: The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate...
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A Comparison of Vancomycin and Metronidazole for the Treatment of Clostridium difficile-associated Diarrhea (CDAD) in Medical Intensive Care Unit (MICU)

Cho EA, Lee KA, Kim JS, Kim SH, Son ES

BACKGROUND: Clostridium difficile associated diarrhea (CDAD) is a leading cause of hospital-associated gastrointestinal illness. Risk factors for CDAD include advanced age, long-term admission, antibiotics, proton-pump inhibitor or Hâ‚‚ blocker use...
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Effect of Metronidazole in Infants with Bowel Habit Change: Irrelative to the Clostridium difficile Colonization

Kim EJ, Lee SH, Tchah H, Ryoo E

PURPOSE: Clinical symptoms associated with Clostridium difficile infection (CDI) can vary widely. Carrier state without apparent symptoms is relatively common during infancy. The objective of this study was to determine...
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