J Korean Diabetes.  2011 Dec;12(4):245-247. 10.4093/jkd.2011.12.4.245.

A Case of Acetone Intoxication Misdiagnosed as Diabetic Ketoacidosis

Affiliations
  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea. drkwon@catholic.ac.kr

Abstract

Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes. The triad of uncontrolled hyperglycemia, metabolic acidosis, and increased total body ketone concentration characterizes DKA. Not all patients with ketoacidosis have DKA, and other situations can result in metabolic acidosis and ketonemia, like starvation ketosis, alcoholic ketoacidosis or ingestion of drugs such as salicylate, methanol, ethylene glycol. We report a case of acetone intoxication that was misdiagnosed as diabetic ketoacidosis.

Keyword

Diabetic ketoacidosis; Acetone intoxication; Acidosis

MeSH Terms

Acetone
Acidosis
Alcoholics
Diabetic Ketoacidosis
Eating
Ethylene Glycol
Ethylenes
Humans
Hyperglycemia
Ketosis
Methanol
Starvation
Acetone
Ethylene Glycol
Ethylenes
Methanol

Reference

1. Kim S. Burden of hospitalizations primarily due to uncontrolled diabetes: implications of inadequate primary health care in the United States. Diabetes Care. 2007; 30:1281–2.
2. Kitabchi AE, Umpierrez GE, Fisher JN, Murphy MB, Stentz FB. Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state. J Clin Endocrinol Metab. 2008; 93:1541–52.
Article
3. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009; 32:1335–43.
Article
4. Ramu A, Rosenbaum J, Blaschke TF. Disposition of acetone following acute acetone intoxication. West J Med. 1978; 129:429–32.
5. Gamis AS, Wasserman GS. Acute acetone intoxication in a pediatric patient. Pediatr Emerg Care. 1988; 4:24–6.
Article
6. Tridgell DM, Tridgell AH, Hirsch IB. Inpatient management of adults and children with type 1 diabetes. Endocrinol Metab Clin North Am. 2010; 39:595–608.
Article
7. 19.Ennis ED, Stahl EJVB, Kreisberg RA. The hyperosmolar hyperglycaemic syndrome. Diabetes Rev. 1994; 2:115–26.
8. Kitabchi AE, Umpierrez GE, Murphy MB, Barrett EJ, Kreisberg RA, Malone JI, Wall BM. American Diabetes Association. Hyperglycemic crises in diabetes. Diabetes Care. 2004; 27(Suppl 1):S94–102.
9. Prevost M, Sun Y, Servilla KS, Massie L, Glew RH, Tzamaloukas AH. Repeated intoxication presenting with azotemia, elevated serum osmolal gap, and metabolic acidosis with high anion gap: differential diagnosis, management, and prognosis. Int Urol Nephrol 2010 Jul 4 [Epub].http://dx.doi.org/10.1007/s11255-010-9796-6.
10. Sung I, Kwon OY, Kang H, Kim D, Kim Y, Park KJ, Choi NC, Lim BH. A case of Parkinsonism caused by acetone intoxication. J Korean Neurol Assoc. 2003; 21:422–5.
11. Jones AW. Elimination half-life of acetone in humans: case reports and review of the literature. J Anal Toxicol. 2000; 24:8–10.
Article
12. Celik U, Celik T, Avci A, Annagur A, Yilmaz HL, Kucukosmanoglu O, Topaloglu AK, Daglioglu N. Metabolic acidosis in a patient with type 1 diabetes mellitus complicated by methanol and amitriptyline intoxication. Eur J Emerg Med. 2009; 16:45–8.
Article
13. Davis LE, Hudson D, Benson BE, Jones Easom LA, Coleman JK. Methanol poisoning exposures in the United States: 1993-1998. J Toxicol Clin Toxicol. 2002; 40:499–505.
Article
14. Höjer J. Severe metabolic acidosis in the alcoholic: differential diagnosis and management. Hum Exp Toxicol. 1996; 15:482–8.
Article
15. Caravati EM, Litovitz TL. Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic. JAMA. 1988; 260:3470–3.
Article
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