J Korean Diabetes.  2012 Jun;13(2):105-109. 10.4093/jkd.2012.13.2.105.

Insulin Autoimmune Syndrome with Diabetic Ketoacidosis

Affiliations
  • 1Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea. yeojoo@schmc.ac.kr

Abstract

Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, elevated insulin level and a high level of insulin autoantibodies without previous insulin exposure. Among the clinical manifestations of insulin autoimmune syndrome, diabetic ketoacidosis is extremely rare. A 72-year-old diabetic woman was hospitalized with diabetic ketoacidosis. She suffered repeated fasting hypoglycemia after treatment of the diabetic ketoacidosis. Here we describe this case of insulin autoimmune syndrome manifested as diabetic ketoacidosis followed by recurrent hypoglycemia with a review of the relevant literature.

Keyword

Diabetic ketoacidosis; Hypoglycemia; Insulin autoantibody

MeSH Terms

Aged
Autoantibodies
Diabetic Ketoacidosis
Female
Humans
Hypoglycemia
Insulin
Autoantibodies
Insulin

Figure

  • Fig. 1 This figure shows that hypoglycemia was occurred at 360 min of 75 g oral glucose tolerance test.

  • Fig. 2 Abdominal computed tomography scan shows no evidence of any pancreatic mass.


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