J Korean Diabetes Assoc.  2006 Jul;30(4):312-315. 10.4093/jkda.2006.30.4.312.

A Case of Acromegaly Presenting with Diabetic Ketoacidosis

• Kim JD
• Sohn TS
• Lee JI
• Hah JH
• Jung YH
• Lee JM
• Nam SM
• Lee SW
• Son HS

• KMID: 2177603
• DOI: http://doi.org/10.4093/jkda.2006.30.4.312

Abstract

In patients with acromegaly, glucose intolerance and diabetes mellitus are one of the frequent manifestations. And the type of diabetes in these patients is usually non-insulin dependent type secondary to insulin resistance caused by growth hormone excess. Therefore, the diabetes mellitus in these patients dose not tend to develop diabetic ketoacidosis. But we experienced and presented the case of a patient with acromegaly hospitalized due to the diabetic ketoacidosis without overt clinical manifestations of acromegaly. This case of acromegaly showed that growth hormone excess could cause diabetic ketoacidosis in the presence of relative insulin deficiency.

Keyword

Acromegaly; Diabetic ketoacidosis; Insulin resistance; Growth hormone

MeSH Terms

Acromegaly*
Diabetes Mellitus
Diabetic Ketoacidosis*
Glucose Intolerance
Growth Hormone
Humans
Insulin
Insulin Resistance
Growth Hormone
Insulin

Figure

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  Fig. 1 Sella MRI. T1 weighted sagittal view of sella MRI showed an 2.5 × 2 cm sized multilobulated solid mass involving the sella and suprasella region with mild indentation of the inferior aspect of the optic chiasm (A). Post-op sella MRI showed remaining solid mass especially involving the suprasella region with low-signal intensity (B).

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