Yeungnam Univ J Med.  2012 Dec;29(2):73-76. 10.12701/yujm.2012.29.2.73.

Obesity and Insulin Resistance in Childhood

• Choi KH

• KMID: 2049801
• DOI: http://doi.org/10.12701/yujm.2012.29.2.73

Abstract

More and more children are becoming obese and overweight due to several factors that include a high energy density in the diet (a high fat intake) and low energy expenditure. Consequently childhood obesity is becoming a significant health problem. Fat tissue releases many cytokines such as resistin, tumor necrosis factor-alpha, leptin, interleukin-6. These adipocytokines induce obesity-related insulin resistance. Insulin resistance is a key component of obesity-related metabolic problems such as hypertension, type 2 diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, acanthosis nigricans and polycystic ovarian syndrome. This review article focused on insulin resistance and its related metabolic diseases.

Keyword

Childhood obesity; Insulin resistance; hypertension; Non-alcoholic steatohepatitis; Polycystic ovarian syndrome

MeSH Terms

Acanthosis Nigricans
Adipokines
Child
Cytokines
Diabetes Mellitus, Type 2
Diet
Dyslipidemias
Energy Metabolism
Fatty Liver
Humans
Hypertension
Insulin
Insulin Resistance
Interleukin-6
Leptin
Metabolic Diseases
Obesity
Overweight
Polycystic Ovary Syndrome
Resistin
Tumor Necrosis Factor-alpha
Adipokines
Cytokines
Insulin
Interleukin-6
Leptin
Resistin
Tumor Necrosis Factor-alpha