Arch Plast Surg.  2014 Jan;41(1):35-39. 10.5999/aps.2014.41.1.35.

Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

• Cho MK
• An JM
• Kim CH
• Kang SG

• KMID: 2047886
• DOI: http://doi.org/10.5999/aps.2014.41.1.35

Abstract

BACKGROUND
Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.
METHODS
Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.
RESULTS
Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.
CONCLUSIONS
Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.

Keyword

Skin; Diabetes mellitus

MeSH Terms

Aurora Kinase A*
Blotting, Western
Cytokinesis
Diabetes Mellitus
DNA Damage
Humans
Mitosis
Skin*