- Autophagy, Cellular Aging and Age-related Human Diseases
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Cheon SY, Kim H, Rubinsztein DC, Lee JE
- KMID: 2468882
- Exp Neurobiol.
- 2019 Dec;28(6):643-657.
- doi: 10.5607/en.2019.28.6.643
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of... -
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- Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion
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Chatla S, Wilson AF, Pang Q
- KMID: 2465886
- Int J Stem Cells.
- 2019 Nov;12(3):457-462.
- doi: 10.15283/ijsc19074
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of the non-homologous end-joining (NHEJ) activity... -
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- ICSI using fresh and frozen PESA-TESA spermatozoa to examine assisted reproductive outcome retrospectively
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Javed A, Ramaiah MK, Talkad MS
- KMID: 2462121
- Obstet Gynecol Sci.
- 2019 Nov;62(6):429-437.
- doi: 10.5468/ogs.2019.62.6.429
OBJECTIVE: The male reproductive system generates, accumulates, and transports the sperm. In this study, 2 methods of surgically retrieving sperm, namely, testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration... -
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- Consequences of chemotherapeutic agents on primordial follicles and future clinical applications
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Kim SY, Cho GJ, Davis JS
- KMID: 2462115
- Obstet Gynecol Sci.
- 2019 Nov;62(6):382-390.
- doi: 10.5468/ogs.2019.62.6.382
The ovarian reserve is necessary for female fertility and endocrine health. Commonly used cancer therapies diminish the ovarian reserve, thus, resulting in primary ovarian insufficiency, which clinically presents as infertility... -
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- Changes in the constituents and UV-photoprotective activity of Astragalus membranaceus caused by roasting
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Park JY, Lee JY, Kim HD, Jang GY, Seo KH
- KMID: 2461455
- J Nutr Health.
- 2019 Oct;52(5):413-421.
- doi: 10.4163/jnh.2019.52.5.413
PURPOSE: Astragalus membranaceus (AM) is an important traditional medicinal herb. Pharmacological research has indicated that AM has various physiological activities such as antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, and hepatoprotective... -
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- Experimental modeling of the acute toxicity and cytogenotoxic fate of composite mixtures of chromate, copper and arsenate oxides associated with CCA preservative using Clarias gariepinus (Burchell 1822)
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Fagbenro O, Alimba CG, Bakare AA
- KMID: 2470822
- Environ Anal Health Toxicol.
- 2019 Sep;34(3):e2019010.
- doi: 10.5620/eaht.e2019010
Concurrent occurrence of chromium (Cr), copper (Cu) and arsenic (As) from chromated copper arsenate (CCA) wood preservative in aquatic ecosystems demands that their joint-actions in eliciting toxic effects be assessed... -
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- Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention
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Yildiz A, Kaya Y, Tanriverdi O
- KMID: 2468796
- J Cancer Prev.
- 2019 Sep;24(3):146-154.
- doi: 10.15430/JCP.2019.24.3.146
Cancer is the most common cause of death worldwide. Annually, more than ten million new cancer cases are diagnosed, and more than six million deaths occur due to cancer. Nonetheless,... -
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- Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer
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An AR, Kim KM, Park HS, Jang KY, Moon WS, Kang MJ, Lee YC, Kim JH, Chae HJ, Chung MJ
- KMID: 2454601
- J Pathol Transl Med.
- 2019 Jul;53(4):217-224.
- doi: 10.4132/jptm.2019.02.20
BACKGROUND: Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes,... -
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- Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer
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Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ
- KMID: 2454308
- Cancer Res Treat.
- 2019 Jul;51(3):1167-1179.
- doi: 10.4143/crt.2018.526
PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Dietary Antioxidant Intake in Relation to Semen Quality Parameters in Infertile Men: a Cross-Sectional Study
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Rahimlou M, Sohaei S, Nasr-Esfahani M, Nouri M
- KMID: 2454080
- Clin Nutr Res.
- 2019 Jul;8(3):229-237.
- doi: 10.7762/cnr.2019.8.3.229
The objective of this study was to assess the association between dietary antioxidant intake and semen quality parameters in infertile men. In this cross-sectional study, dietary antioxidant intake was evaluated... -
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- Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro
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Koh HK, Seo SY, Kim JH, Kim HJ, Chie EK, Kim SK, Kim IH
- KMID: 2464415
- Cancer Res Treat.
- 2019 Apr;51(2):696-705.
- doi: 10.4143/crt.2018.249
PURPOSE: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on... -
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- Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
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Lee M, Lee KH, Min A, Kim J, Kim S, Jang H, Lim JM, Kim SH, Ha DH, Jeong WJ, Suh KJ, Yang YW, Kim TY, Oh DY, Bang YJ, Im SA
- KMID: 2464392
- Cancer Res Treat.
- 2019 Apr;51(2):451-463.
- doi: 10.4143/crt.2017.341
PURPOSE: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric... -
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- Anti-inflammatory effects of fruit and leaf extracts of Lycium barbarum in lipopolysaccharide-stimulated RAW264.7 cells and animal model
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Bae SM, Kim JE, Bae EY, Kim KA, Ly SY
- KMID: 2444936
- J Nutr Health.
- 2019 Apr;52(2):129-138.
- doi: 10.4163/jnh.2019.52.2.129
PURPOSE: Medicinal herbs have recently attracted attention as health beneficial foods and source materials for drug development. Recent studies have demonstrated that extracts of Lycium's fruits and roots have a... -
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- Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis
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Kim JW, Jeong JH
- KMID: 2444199
- Korean J Neurotrauma.
- 2019 Apr;15(1):2-10.
- doi: 10.13004/kjnt.2019.15.e2
OBJECTIVE: Astrocyte dysfunctions are related to several central nervous system (CNS) pathologies. Transcriptomic profiling of human mRNAs to investigate astrocyte functions may provide the basic molecular-biological data pertaining to the... -
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- Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
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Wang Z, Gao J, Zhou J, Liu H, Xu C
- KMID: 2457138
- J Gynecol Oncol.
- 2019 Mar;30(2):e26.
- doi: 10.3802/jgo.2019.30.e26
OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP... -
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- Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells
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Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M
- KMID: 2447235
- Int J Stem Cells.
- 2019 Mar;12(1):170-182.
- doi: 10.15283/ijsc18051
OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA... -
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- Antioxidant activity of ethanol extract of Lycium barbarum's leaf with removal of chlorophyll
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Kim JE, Bae SM, Nam YR, Bae EY, Ly SY
- KMID: 2466680
- J Nutr Health.
- 2019 Feb;52(1):26-35.
- doi: 10.4163/jnh.2019.52.1.26
PURPOSE: The aim of this study was to estimate the antioxidant activities of 50%, 70%, and 100% ethanol extracts of Lycium barbarum leaf and chlorophyll removal extract. METHODS: The antioxidant activities... -
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- Pathogenesis and prevention of skin cancer
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Oh BH
- KMID: 2426473
- J Korean Med Assoc.
- 2018 Nov;61(11):644-648.
- doi: 10.5124/jkma.2018.61.11.644
The incidence of skin cancer has continuously increased in Korea, probably due to sun exposure and increases in the aging population. Ultraviolet light, a well-known risk factor for skin cancer,... -
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- CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer
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Chang H, Wei JW, Tao YL, Ding PR, Xia YF, Gao YH, Xiao WW
- KMID: 2424793
- Cancer Res Treat.
- 2018 Oct;50(4):1203-1213.
- doi: 10.4143/crt.2017.538
PURPOSE: This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity... -
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