Exp Mol Med.  2004 Dec;36(6):505-509.

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

• Seo YR
• Jung HJ

Abstract

The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles in DNA repair responses to genotoxic stresses. UV-damage and the damage caused by certain chemotherapeutics including cisplatin and nitrogen mustards are known to be repaired by the nucleotide excision repair (NER) pathway which is reportedly regulated by p53 and its downstream genes. There are evidences to suggest that the base excision repair (BER) induced by the base-damaging agent methyl methanesulfonate (MMS) is partially deficient in cells lacking functional p53. This result suggests that the activity of BER might be also dependent on the p53 status. In this review, we discuss the possibilities that p53 regulates BER as well as NER; these are one of the most significant potentials of p53 tumor suppressor for repairing the vast majority of DNA damages that is incurred from various environmental stresses.

Keyword

DNA damage; DNA polymerase beta; DNA repair; DNA repair enzymes; nucleotide excision repair (NER); protein p53

MeSH Terms

Animals
Antineoplastic Agents/pharmacology
DNA/drug effects
*DNA Damage
DNA Repair/*physiology
Humans
Mice
Protein p53/*physiology
Research Support, Non-U.S. Gov't