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Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele

Finelli R, Leisegang K, Kandil H, Agarwal A

Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common...
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8-Hydroxy-2’-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis

Goh XX, Tang PY, Tee SF

Objective Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Thus,...
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The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review

Ambar RF, Agarwal A, Majzoub A, Vij S, Tadros NN, Cho CL, Parekh N, Borges Jr. E, Glina S

The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of...
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Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective

Koedrith P, Rahman M, Jang YJ, Shin DY, Seo YR

The exponential growth of nanotechnology and the industrial production have raised concerns over its impact on human and environmental health and safety (EHS). Although there has been substantial progress in...
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Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes

Jeong HY, Yoo J, Kim H, Kim TM

Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely...
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Dynamic Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Adult Attention Deficit Hyperactivity Disorder

Kurhan F, Alp HH

Objective: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide...
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Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing

Wang HY, Deng L, Li YQ, Zhang X, Long YK, Zhang X, Feng YF, He Y, Tang T, Yang XH, Wang F

Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different...
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Standard Semen Parameters vs. Sperm Kinematics to Predict Sperm DNA Damage

Aghazarian A, Huf W, Pflüger H, Klatte T

Purpose: The aims of this study were to associate sperm kinematics and standard semen parameters with sperm DNA damage and to evaluate whether the addition of sperm kinematics improve the...
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Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus

Oladokun EI, Sogbanmu TO, Anikwe JC

Non-target aquatic organisms such as fish may be impacted by agricultural activities through the run-off of pesticides from farms into aquatic ecosystems. In this study, the genotoxic (erythrocytic micronuclei) and...
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Tube Voltage, DNA Double-Strand Breaks, and Image Quality in Coronary CT Angiography

Lin ZX, Zhou F, Schoepf UJ, Pillai B, Zhou CS, Quan W, Bao XQ, Lu GM, Zhang LJ

Objective: To evaluate the effects of tube voltage on image quality in coronary CT angiography (CCTA), the estimated radiationdose, and DNA double-strand breaks (DSBs) in peripheral blood lymphocytes to optimize...
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Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Bang JH, Oh KS, Seo HR, Oh DY, Bang YJ

Purpose Currently, the DNA damage response (DDR) pathway represents a key target for new cancer drug development. Advanced biliary tract cancer (BTC) has a poor prognosis because of the lack of...
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Activation of ATM/Akt/CREB/eNOS Signaling Axis by Aphidicolin Increases NO Production and Vessel Relaxation in Endothelial Cells and Rat Aortas

Park JH, Cho DH, Hwang YJ, Lee JY, Lee HJ, Jo I

Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been...
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Therapeutic Co-targeting of WEE1 and ATM Downregulates PD-L1 Expression in Pancreatic Cancer

Jin MH, Nam AR, Park JE, Bang JH, Bang YJ, Oh DY

Purpose Pancreatic cancer (PC) is one of the most lethal cancers worldwide, but there are currently no effective treatments. The DNA damage response (DDR) is under investigation for the development of...
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Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ

PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer...
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Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro

Koh HK, Seo SY, Kim JH, Kim HJ, Chie EK, Kim SK, Kim IH

PURPOSE: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on...
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Autophagy, Cellular Aging and Age-related Human Diseases

Cheon SY, Kim H, Rubinsztein DC, Lee JE

Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of...
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Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion

Chatla S, Wilson AF, Pang Q

Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of the non-homologous end-joining (NHEJ) activity...
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Changes in the constituents and UV-photoprotective activity of Astragalus membranaceus caused by roasting

Park JY, Lee JY, Kim HD, Jang GY, Seo KH

PURPOSE: Astragalus membranaceus (AM) is an important traditional medicinal herb. Pharmacological research has indicated that AM has various physiological activities such as antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, and hepatoprotective...
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Effects of glutathione s-transferase (GST) M1 and T1 polymorphisms on antioxidant vitamins and oxidative stress-related parameters in Korean subclinical hypertensive subjects after kale juice (Brassica oleracea acephala) supplementation

Lee HJ, Han JH, Park YK, Kang MH

BACKGROUND/OBJECTIVES: Glutathione s-transferase (GST) is involved in the formation of a multigene family comprising phase II detoxification enzymes, involved in the detoxification of reactive oxygen species. This study evaluated whether...
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CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer

Chang H, Wei JW, Tao YL, Ding PR, Xia YF, Gao YH, Xiao WW

PURPOSE: This study aimed to explore the functions and mechanisms of C-C motif chemokine receptor 6 (CCR6), a gene associated with progression and metastasis of colorectal cancer (CRC), in radiosensitivity...
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