- Analysis of Plasma Circulating Tumor DNA in Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Modified FOLFIRINOX: Clinical Relevance of DNA Damage Repair Gene Alteration Detection
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Lim DH, Yoon H, Kim Kp, Ryoo BY, Lee SS, Park DH, Song TJ, Hwang DW, Lee JH, Song KB, Kim SC, Hong SM, Hyung J, Yoo C
- KMID: 2547805
- Cancer Res Treat.
- 2023 Oct;55(4):1313-1320.
- doi: 10.4143/crt.2023.452
Purpose There are no reliable biomarkers to guide treatment for patients with borderline resectable pancreatic cancer (BRPC) in the neoadjuvant setting. We used plasma circulating tumor DNA (ctDNA) sequencing to... -
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- Germline DNA-Repair Genes and HOXB13 Mutations in Korean Men with Metastatic Prostate Cancer: Data from a Large Korean Cohort
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Song SH, Kim HM, Jung YJ, Kook HR, Jeon S, Bhak J, Kim JH, Lee H, Oh JJ, Lee S, Hong SK, Byun SS
- KMID: 2546307
- World J Mens Health.
- 2023 Oct;41(4):960-968.
- doi: 10.5534/wjmh.220190
Purpose Germline mutations in DNA damage repair (DDR) genes such as BRCA2 have been associated with prostate cancer (PC) risk but has not been thoroughly evaluated for metastatic prostate cancer (mPC)... -
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- Ethanol Extract of Smilax glabra Induces Apoptotic Cell Death in Human YD10B Oral Squamous Cell Carcinoma Cells
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Hwang YS
- KMID: 2546581
- J Dent Hyg Sci.
- 2023 Sep;23(3):216-224.
- doi: 10.17135/jdhs.2023.23.3.216
Background: Smilax glabra has various pharmacological activities and is widely used as a herbal medicine. Although the incidence of oral cancer is low, the recurrence rate is high, and the... -
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- Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage
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Kim JH, Patel R
- KMID: 2545533
- Korean J Physiol Pharmacol.
- 2023 Sep;27(5):427-436.
- doi: 10.4196/kjpp.2023.27.5.427
Mitotic arrest deficient 2 like 2 (Mad2L2, also known as Mad2B), the human homologue of the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares high... -
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- Transition nuclear protein 1 as a novel biomarker in patients with fertilization failure
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Mirsanei JS, Gholipour H, Zandieh Z, Jahromi MG, Masroor MJ, Mehdizadeh M, Amjadi F
- KMID: 2545468
- Clin Exp Reprod Med.
- 2023 Sep;50(3):185-191.
- doi: 10.5653/cerm.2023.05890
Objective: Although intracytoplasmic sperm injection (ICSI) is a way to deal with in vitro fertilization failure, 3% of couples still experience repeated fertilization failure after attempted ICSI, despite having sperm... -
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- Inactivation of Mad2B Enhances Apoptosis in Human Cervical Cancer Cell Line upon Cisplatin-Induced DNA Damage
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Kim JH, Kim HR, Patel R
- KMID: 2541793
- Biomol Ther.
- 2023 May;31(3):340-349.
- doi: 10.4062/biomolther.2022.130
Mad2B (Mad2L2), the human homolog of the yeast Rev7 protein, is a regulatory subunit of DNA polymerase ζ that shares sequence similarity with the mitotic checkpoint protein Mad2A. Previous studies... -
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- Genomic Correlates of Unfavorable Outcome in Locally Advanced Cervical Cancer Treated with Neoadjuvant Chemoradiation
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Wei Y, Wei C, Chen L, Liu N, Ou Q, Yin JC, Pang J, Fang Z, Wu X, Wang X, Mu D, Shao Y, Yu J, Yuan S
- KMID: 2534200
- Cancer Res Treat.
- 2022 Oct;54(4):1209-1218.
- doi: 10.4143/crt.2021.963
Purpose Neoadjuvant therapy modality can increase the operability rate and mitigate pathological risks in locally advanced cervical cancer, but treatment response varies widely. It remains unclear whether genetic alterations correlate with... -
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- Analysis of the global gene expression profiles in genomic instability-induced cervical cancer cells
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Oh JM
- KMID: 2530746
- Int J Oral Biol.
- 2022 Jun;47(2):17-24.
- doi: 10.11620/IJOB.2022.47.2.17
Preserving intact genetic material and delivering it to the next generation are the most significant tasks of living organisms. The integrity of DNA sequences is under constant threat from endogenous... -
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- The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder
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Kurhan F, Alp HH, Işık M, Atan YS
- KMID: 2530454
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):240-247.
- doi: 10.9758/cpn.2022.20.2.240
Objective: In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods: Thirty-five patients previously diagnosed with OCD... -
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- Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer
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Seo HR, Nam AR, Bang JH, Oh KS, Kim JM, Yoon J, Kim TY, Oh DY
- KMID: 2528223
- Cancer Res Treat.
- 2022 Apr;54(2):541-553.
- doi: 10.4143/crt.2021.473
Purpose Up to 20% of patients with biliary tract cancer (BTC) have alterations in DNA damage response (DDR) genes, including homologous recombination (HR) genes. Therefore, the DDR pathway could be... -
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- Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele
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Finelli R, Leisegang K, Kandil H, Agarwal A
- KMID: 2523639
- World J Mens Health.
- 2022 Jan;40(1):87-103.
- doi: 10.5534/wjmh.210153
Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common... -
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- Correlation-based and feature-driven mutation signature analyses to identify genetic features associated with DNA mutagenic processes in cancer genomes
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Jeong HY, Yoo J, Kim H, Kim TM
- KMID: 2524331
- Genomics Inform.
- 2021 Dec;19(4):e40.
- doi: 10.5808/gi.21047
Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely... -
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- Dynamic Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Adult Attention Deficit Hyperactivity Disorder
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Kurhan F, Alp HH
- KMID: 2522981
- Clin Psychopharmacol Neurosci.
- 2021 Nov;19(4):731-738.
- doi: 10.9758/cpn.2021.19.4.731
Objective: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide... -
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- Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing
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Wang HY, Deng L, Li YQ, Zhang X, Long YK, Zhang X, Feng YF, He Y, Tang T, Yang XH, Wang F
- KMID: 2521573
- Cancer Res Treat.
- 2021 Oct;53(4):973-982.
- doi: 10.4143/crt.2020.798
Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different... -
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- 8-Hydroxy-2’-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis
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Goh XX, Tang PY, Tee SF
- KMID: 2518577
- Psychiatry Investig.
- 2021 Jul;18(7):603-618.
- doi: 10.30773/pi.2020.0417
Objective Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Thus,... -
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- The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review
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Ambar RF, Agarwal A, Majzoub A, Vij S, Tadros NN, Cho CL, Parekh N, Borges Jr. E, Glina S
- KMID: 2516695
- World J Mens Health.
- 2021 Jul;39(3):391-398.
- doi: 10.5534/wjmh.200084
The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of... -
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- Nanoparticles: Weighing the Pros and Cons from an Eco-genotoxicological Perspective
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Koedrith P, Rahman M, Jang YJ, Shin DY, Seo YR
- KMID: 2517360
- J Cancer Prev.
- 2021 Jun;26(2):83-97.
- doi: 10.15430/JCP.2021.26.2.83
The exponential growth of nanotechnology and the industrial production have raised concerns over its impact on human and environmental health and safety (EHS). Although there has been substantial progress in... -
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- Standard Semen Parameters vs. Sperm Kinematics to Predict Sperm DNA Damage
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Aghazarian A, Huf W, Pflüger H, Klatte T
- KMID: 2509587
- World J Mens Health.
- 2021 Jan;39(1):116-122.
- doi: 10.5534/wjmh.190095
Purpose: The aims of this study were to associate sperm kinematics and standard semen parameters with sperm DNA damage and to evaluate whether the addition of sperm kinematics improve the... -
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- Activation of ATM/Akt/CREB/eNOS Signaling Axis by Aphidicolin Increases NO Production and Vessel Relaxation in Endothelial Cells and Rat Aortas
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Park JH, Cho DH, Hwang YJ, Lee JY, Lee HJ, Jo I
- KMID: 2508210
- Biomol Ther.
- 2020 Nov;28(6):549-560.
- doi: 10.4062/biomolther.2020.007
Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been... -
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- Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus
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Oladokun EI, Sogbanmu TO, Anikwe JC
- KMID: 2511316
- Environ Anal Health Toxicol.
- 2020 Sep;35(3):e2020013.
- doi: 10.5620/eaht.2020013
Non-target aquatic organisms such as fish may be impacted by agricultural activities through the run-off of pesticides from farms into aquatic ecosystems. In this study, the genotoxic (erythrocytic micronuclei) and... -
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