Anat Cell Biol.  2013 Dec;46(4):229-234. 10.5115/acb.2013.46.4.229.

Adiponectin as a new paradigm for approaching Alzheimer's disease

• Song J
• Lee JE

• KMID: 2046762
• DOI: http://doi.org/10.5115/acb.2013.46.4.229

Abstract

Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer's disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Previous studies demonstrated that adiponectin modulates memory and cognitive impairment and contributes to the deregulated glucose metabolism and mitochondrial dysfunction observed in Alzheimer's disease. Here, we aim to summarize recent studies that suggest the potential correlation between adiponectin and Alzheimer's disease.

Keyword

Adiponectin; Alzheimer's disease; Brain insulin system; Cognitive impairment

MeSH Terms

Adiponectin*
Adipose Tissue
Alzheimer Disease*
Cardiovascular Diseases
Glucose
Homeostasis
Immune System
Insulin
Memory
Metabolism
Neurodegenerative Diseases
Obesity
Adiponectin
Glucose
Insulin

Figure

• 

  Fig. 1 The phospholylation of insulin receptor substrate (IRS)-1 in streptozotocin (STZ) induced dementia rat model. To confirm the dysfunction of brain insulin system in STZ-induced dementia rat model known as common animal model to study Alzheimer's disease in vivo, we conducted immunohistochemistry using phospho IRS-1 antibody. (A) In the hippocampus, phospholylation of IRS-1 decreased in the STZ induced dementia group compared with sham (control group). (B) In the cortex, phospholylation of IRS-1 decreased in the STZ induced dementia group compared with sham (control group). Green color, phospho IRS-1; red color, propidium iodide (PI).

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