Korean Diabetes J.  2010 Aug;34(4):237-243. 10.4093/kdj.2010.34.4.237.

The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults

• Jung CH
• Rhee EJ
• Choi JH
• Bae JC
• Yoo SH
• Kim WJ
• Park CY
• Mok JO
• Kim CH
• Lee WY
• Oh KW
• Park SW
• Kim SW

• KMID: 2029877
• DOI: http://doi.org/10.4093/kdj.2010.34.4.237

Abstract

BACKGROUND
We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.
METHODS
Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.
RESULTS
Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.
CONCLUSION
A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.

Keyword

Adiponectin/leptin ratio; Insulin resistance; Metabolic syndrome

MeSH Terms

Adiponectin
Adipose Tissue
Adult
Body Mass Index
Electric Impedance
Enzyme-Linked Immunosorbent Assay
Fasting
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Leptin
Male
Radioimmunoassay
Risk Factors
Adiponectin
Glucose
Insulin
Leptin

Figure

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  Fig. 1 The comparison of mean values for (A) leptin, (B) HOMA-IR, and (C) A/L ratio according to the number of metabolic syndrome components. A/L ratio, adiponectin/leptin ratio; HOMA-IR, homeostasis model assessment-insulin resistance; MS, metabolic syndrome.

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