Yonsei Med J.
2017 Mar;58(2):339-346. 10.3349/ymj.2017.58.2.339.
Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study
- Affiliations
-
- 1Department of Humanities and Social Medicine, Ajou University School of Medicine, Suwon, Korea.
- 2Department of Preventive Medicin, Yonsei University Wonju College of Medicine, Wonju, Korea. dodge@yonsei.ac.kr
- 3Institute of Genomic Cohort, Yonsei University, Wonju, Korea.
- 4Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- KMID: 2427122
- DOI: http://doi.org/10.3349/ymj.2017.58.2.339
Abstract
- PURPOSE
The ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on improvement of metabolic components in high-risk individuals with metabolic syndrome. We examined the association between L/A ratio and the regression of metabolic syndrome in a population-based longitudinal study.
MATERIALS AND METHODS
A total of 1017 subjects (431 men and 586 women) with metabolic syndrome at baseline (2005-2008) were examined and followed (2008-2011). Baseline serum levels of leptin and adiponectin were analyzed by radioimmunoassay. Area under the receiver operating characteristics curve (AUROC) analyses were used to assess the predictive ability of L/A ratio for the regression of metabolic syndrome.
RESULTS
During an average of 2.8 years of follow-up, metabolic syndrome disappeared in 142 men (32.9%) and 196 women (33.4%). After multivariable adjustment, the odds ratios (95% confidence interval) for regression of metabolic syndrome in comparisons of the lowest to the highest tertiles of L/A ratio were 1.84 (1.02-3.31) in men and 2.32 (1.37-3.91) in women. In AUROC analyses, L/A ratio had a greater predictive power than serum adiponectin for the regression of metabolic syndrome in both men (p=0.024) and women (p=0.019).
CONCLUSION
Low L/A ratio is a predictor for the regression of metabolic syndrome. The L/A ratio could be a useful clinical marker for management of high-risk individuals with metabolic syndrome.
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