Korean J Occup Health Nurs.  2009 May;18(1):44-54.

Effects of Obesity on the Physiological Levels of Adiponectin, Leptin and Diagnostic Indices of Metabolic Syndrome in Male Workers

• Heo KH
• Won YL
• Ko KS
• Kim KW

Abstract

PURPOSE: The aim of this study was to examine the effects of obesity on the physiological levels of adiponectin, leptin and components of metabolic syndrome (MS) in male workers, aged 30-40 years.
METHODS
Body mass index (BMI) was measured with Anthropometric equipment. Blood pressure and serum parameters were measured with an automatic digital sphygmomanometer and autochemical analyzer, respectively. Adiponectin and leptin were analysed by ELISA kits and MS was defined based on the NCEP-ATP III.
RESULTS
Body fat mass of waist and hip, systolic and diastolic blood pressure were significantly higher, as expected, in the BMI> 25kg/m2 in comparison with the BMI< or =25kg/m2. While fasting glucose, insulin, HOMA-IR and leptin in the BMI>25kg/m2 were also significantly higher compared with BMI< or =25kg/m2, HDL- cholesterol and adiponectin were significantly higher in BMI< or =25kg/m2. On multiple logistic regression analysis for the components of MS, exercise, adiponectin and leptin were an only independent factor for MS in non-obese male workers(BMI< or =25kg/m2) after adjustment for age, cigarette smoking and drinking habits.
CONCLUSION
These results suggested that the obesity in men was associated with physiological levels of adiponectin and leptin contributing to feedback control of MS and that dysfunction and/or declination in feedback control system associated with changes in physiological levels of neurptrophics: adiponectin and leptin might ultimately induce MS.

Keyword

Metabolic syndrome; Adiponectin; Leptin; Male workers

MeSH Terms

Adiponectin
Adipose Tissue
Aged
Blood Pressure
Body Mass Index
Cholesterol
Drinking
Enzyme-Linked Immunosorbent Assay
Fasting
Glucose
Hip
Humans
Insulin
Leptin
Logistic Models
Male
Obesity
Smoking
Sphygmomanometers
Adiponectin
Cholesterol
Glucose
Insulin
Leptin