J Korean Acad Periodontol.  2005 Jun;35(2):401-411. 10.5051/jkape.2005.35.2.401.

Antimicrobial effect of cefixime on 6 species of periodotopathogens

• Jang HS
• Park MG
• Kook JK
• Kim HS
• Kim BO

• KMID: 1999767
• DOI: http://doi.org/10.5051/jkape.2005.35.2.401

Abstract

The aim of this study was to determine the minimal inhibitory concentration(MIC) of cefi- xime, which is a 3rd generation of cefalosporin, against 6 species of putative periodon- topathogens; Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Prevotella inter- media, Prevotella nigrescens, Tannerella forsythia and Porphyromonas gingivalis. The efficacy of cefixime was examined by comparing it with that of several antibiotics(amoxicillin, Aug- mentin(R) ciprofloxacin, metronidazole, and tetracycline), which were used as the control. The MIC was measured using a microdilution method. The MIC of cefixime against the putative periodotopathogens, as a single use regimen, was relatively lower than that of the other antibiotics. The MIC of cefixime/metronidazole against P. intermedia ChDC KB14, P. nigres- cens ChDC KB50, F. nucleatum ChDC PV-F37, F. nucleatum ChDC F130, and F. nucleatum ChDC F175, as a simultaneous regimen, was lower than that of the other antibiotics. The concentration of cefixime in the crevicular fluid of volunteers who received 250mg every 12 hours for 3 days was 9microgram/ml after 9 hours. In conclusion, cefixime showed good anti- microbial activity in a single treatment or as a combined therapy with amoxicillin, Aug- mentin(R) or metronidazole against 6 periodontopathogens.

Keyword

Minimal inhibitory concentraion(MIC); cefixime

MeSH Terms

Aggregatibacter actinomycetemcomitans
Amoxicillin
Anti-Bacterial Agents
Cefixime*
Ciprofloxacin
Forsythia
Fusobacterium nucleatum
Metronidazole
Porphyromonas gingivalis
Prevotella
Prevotella nigrescens
Volunteers
Amoxicillin
Anti-Bacterial Agents
Cefixime
Ciprofloxacin
Metronidazole