In-Vitro Susceptibility Study of Oral Antibiotics to Escherichia coli, Isolated From Acute Uncomplicated Cystitis in Female Outpatients

Sohn, Dong Wan; Ha, U Syn; Seo, Hong Jin; Lee, Ji Youl; Kim, Sae Woong; Cho, Yong Hyun

Abstract

BACKGROUND: The objective of this study was to obtain data on the susceptibility of oral antibiotics to pathogens responsible for acute uncomplicated cystitis in female outpatients.
MATERIALS AND METHODS
We performed urine culture from total of 118 female outpatients with acute uncomplicated cystitis between October 2004 and June 2005. A total of 134 isolates were obtained from female outpatients with acute uncomplicated cystitis. Antimicrobial susceptibilities to ampicillin, amoxicillin, ciprofloxacin, levofloxacin, trimethoprim/sulfamethoxazole (TMP/SMX), and cefixime were determined by Densichek kit (Biomerieux Inc., USA) antimicrobial susceptibility test systems.
RESULTS
The most prevalent causative organism was Escherichia coli (76.1%), followed by P. aeruginosa, S. agalactiae, E. faecium, S. aureus, K. pneumoniae, E. fecalis, E. aerogenes, K. oxytica. The mean rates of susceptibility to each drug were ampicillin 39.25%, amoxicillin 39.2%, ciprofloxacin 69.6%, levofloxacin 72.5%, TMP/SMX 39.2%, and cefixime 87.3%.
CONCLUSION
Escherichia coli was the most important pathogen of acute uncomplicated cystitis in female outpatients. The high prevalence of resistance to ampicillin, amoxicillin and TMP/SMX suggests that they would not provide adequate initial therapy and therapies other than TMP/SMX may need to be considered. The prevalence of resistance to ciprofloxacin was higher than that of previous study. We think that the further evaluation for the pathogen of cystitis and the resistance of antibiotics is necessary.