Korean J Urogenit Tract Infect Inflamm.  2013 Oct;8(2):90-97. 10.14777/kjutii.2013.8.2.90.

Multidrug Resistance in Neisseria gonorrhoeae

• Baik S
• Lim DH

• KMID: 1502113
• DOI: http://doi.org/10.14777/kjutii.2013.8.2.90

Abstract

Gonorrhea, caused by Neisseria gonorrhoeae is the second most prevalent bacterial sexually transmitted infection. The disease causes serious reproductive complications such as pelvic inflammatory disease, ectopic pregnancy, and infertility, and can facilitate human immunodeficiency virus transmission. Numerous antimicrobial agents have been used for the treatment of gonorrhea since sulfanilamides were introduced in 1936. Unfortunately, N. gonorrhoeae readily develops resistance to antimicrobial agents. Strains with decreased susceptibility to oral third generation cephalosporin (cefixime) are currently emerging. The US Centers for Disease Control and Prevention (CDC) no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections, but recommends combination therapy with ceftriaxone 250 mg intramuscularly and either azithromycin 1 g orally as a single dose or doxycycline 100 mg orally twice daily for 7 days as the most reliably effective treatment for uncomplicated gonorrhea.

Keyword

Drug resistance, Multiple; Cefixime; Gonorrhea; Neisseria gonorrhoeae

MeSH Terms

Anti-Infective Agents
Azithromycin
Cefixime
Ceftriaxone
Centers for Disease Control and Prevention (U.S.)
Doxycycline
Drug Resistance, Multiple*
Female
Gonorrhea
HIV
Infertility
Neisseria gonorrhoeae*
Neisseria*
Pelvic Inflammatory Disease
Pregnancy
Pregnancy, Ectopic
Sulfanilamides
Anti-Infective Agents
Azithromycin
Cefixime
Ceftriaxone
Doxycycline
Sulfanilamides

Figure

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  Fig. 1. Study on antimicrobial resistance of Neisseria gonorrhoeae isolated in Korea, 2008-2011.

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  Fig. 2. Annual trend of cefixime minimum inhibitory concentrations of Neisseria gonorrhoeae isolated in Korea.

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  Fig. 3. Annual trend of ceftriaxone minimum inhibitory concentrations of Neisseria gonorrhoeae isolated in Korea.

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