Korean J Psychopharmacol.
2003 Jun;14(2):172-180.
Genetic Association between Single Nucleotide Polymorphisms on COMT Gene and Schizophrenia in Korean Population
- Affiliations
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- 1Department of Psychiatry, School of Medicine, Eulji University, Daejeon, Korea.
- 2Chook Ryoung Evangelical Hospital, Namyangju, Korea.
- 3Seoul National University Hospital, Seoul, Korea.
- 4Department of Biochemistry, School of Medicine, Eulji University, Daejeon, Korea.
- 5Department of Neuropsychiatry, School of Medicine, Chungbuk National University, Cheongju, Korea.
- 6Department of Psychiatry and Behavioral Science, School of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVE
This study aimed to explore genetic relation between schizophrenia and COMT gene which plays an important role in metabolizing dopamine, one of the most intriguing neuro-transmitters for schizophrenia. METHODS: 1) Single Nucleotide Polymorphism (SNP) on exons of COMT gene was searched by F-CSGE (Fluorescent-Conformation Sensitive Gel Electrophoresis) method with 50 patients with schizophrenia to look for any SNP unique to Korean patients with schizophrenia. 2) Genotyping was done for five SNPs on COMT gene for 218 patients with schizophrenia and 199 normal controls by SNaPShot method. Allele frequencies, genotype frequencies and simulated haplotype frequencies were compared between patients with schizophrenia and normal controls. RESULTS: 1) No unique SNPs for Koreans was found on exons of COMT gene and seven SNPs were found, all of them are already reported to be found in other ethnic groups. 2) No significant difference between patients with schizophrenia and normal controls in terms of allele frequencies, genotype frequencies and haplotype frequencies was found in our sample. CONCLUSION: Genetic association between five SNPs on COMT gene and DSM-IV diagnosis of schizophrenia among Koreans was not able to be found in this study.
Keyword
- Schizophrenia; COMT; Gene; SNP; CSGE; Association
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