Epidemiol Health.  2010;32:e2010011.

No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population

• Kang HJ
• Choe BM
• Kim SH
• Son SR
• Lee KM
• Kim BG
• Hong YS

Abstract

OBJECTIVES
Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population.
METHODS
We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk.
RESULTS
Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes.
CONCLUSION
Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.

Keyword

Catechol-O-methyltransferase; Schizophrenia; Methylenetetrahydrofolate reductase; Polymorphism

MeSH Terms

Case-Control Studies
Catechol O-Methyltransferase
Genotype
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide
Schizophrenia
Catechol O-Methyltransferase
Methylenetetrahydrofolate Reductase (NADPH2)