Neurointervention.  2009 Feb;4(1):8-14.

Severe Atherosclerotic Cerebral Steno-occlusion in Koreans: Factors Related to Intracranial versus Extracranial Involvement

• Kim HJ
• Choi BS
• Choi JW
• Kim SM
• In HS
• Kwon HJ
• Kang BK
• Chung SY
• Suh DC

Abstract

PURPOSE
To evaluate the factors related to severe intracranical atherosclerotic stenosis (intracranial vs. extracranial) as diagnosed by conventional angiography in Korean patients.
MATERIALS AND METHODS
We retrospectively analyzed the angiographic results and clinical data of 127 consecutive patients with an angiographically confirmed stenosis greater than 70%. Nine factors, i.e. age, gender, hypertension, diabetes mellitus, hyperlipidemia, smoking and alcohol habit, previous stroke and ischemic heart disease were included as presumed explanatory variables to discriminate different types of atherosclerotic stenosis (extracranial versus intracranial stenosis). Multiple logistic regression analysis was used to estimate independent effects of the predictive variables on cerebral occlusive disease.
RESULTS
Among 127 patients, 62 patients had intracranial stenosis and 65 patients had extracranial stenosis. Compared to extracranial stenosis, mean age was lower (p < 0.001), female-to-male ratio was higher (p = 0.001) and the number of patients with diabetes mellitus was less (p = 0.019) in group of severe intracranial stenosis significantly. There were no differences in hypertension, smoke and alcohol, hyperlipidemia, ischemic heart disease and previous stroke between two groups.
CONCLUSION
In Korean patients, severe atherosclerotic intracranial stenosis has younger, female and diabetes-free preference than severe atherosclerotic extracranial stenosis.

Keyword

Atherosclerosis; Internal carotid artery; Stroke

MeSH Terms

Angiography
Atherosclerosis
Carotid Artery, Internal
Constriction, Pathologic
Diabetes Mellitus
Female
Humans
Hyperlipidemias
Hypertension
Logistic Models
Myocardial Ischemia
Retrospective Studies
Smoke
Smoking
Stroke
Smoke