J Korean Assoc Oral Maxillofac Surg.  2003 Dec;29(6):374-378.

Bone formation using injectable tissue-engineering materials

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University. choibh@wonju.yonsei.ac.kr
  • 2Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine.
  • 3Department of Dentistry, Kangneung Asan Hospital, University of Ulsan.
  • 4Department of Periodontology, College of Medicine, Ewha Womens University.

Abstract

AIM: Several injectable materials have been used in the application of osteogenic bone substitute; however, nothing has won universal acceptance. This study was performed to investigate whether chitosan-alginate gel/MSCs/BMP-2 composites are potentially injectable materials for new bone formation. MATERIAL AND METHODS: The composites were injected into the subcutaneous space on the dorsum of the nude mouse to investigate whether new bone would be tissue engineered in the mouse. The composites were examined histologically over a 12-week period.
RESULTS
The composites implanted in the mouse were able to tissue engineer new bone, and the newly formed bone consisted of trabecular bone and calcified bone matrix.
CONCLUSIONS
The present study shows that chitosan-alginate gel/MSCs/BMP-2 composites have the potential to become real injectable materials for new bone formation.

Keyword

Tissue engineering; Injectable bone; Bone regeneration; Chitosan; Alginate

MeSH Terms

Animals
Bone Matrix
Bone Regeneration
Bone Substitutes
Chitosan
Mice
Mice, Nude
Osteogenesis*
Tissue Engineering
Bone Substitutes
Chitosan
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